Exercise‐induced hyperkalaemia can be reduced in human subjects by moderate training without change in skeletal muscle Na, K‐ATPase concentration

K. KJELDSEN*, A. NØRGAARD, C. HAU

*Corresponding author af dette arbejde

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    Abstract

    Abstract. In 15 conscripts, venous plasma potassium was followed during exercise on a training bicycle before and after 10 weeks of moderate physical training and a putative relationship with skeletal muscle Na, K‐ATPase was evaluated. Peak plasma potassium concentration obtained at exhaustion was 61 pM 0.2 and 5.6 pM 0.2 mmol l‐1 (mean pM SEM, n= 14, P < 0.05) before and after training, respectively. Throughout the exercise period and within the first minutes of rest plasma potassium concentration was 0.2–0.5 mmol l‐1 higher before than after training. Neither peak values nor peak rises in plasma potassium concentration before nor after training were correlated to the 3H‐ouabain binding site (Na, K‐ATPase) concentration in vastus lateralis muscle. The results indicate that net loss of potassium from the skeletal muscle pool during exercise is reduced after training, that the heart during exercise may be exposed to a smaller rise in plasma potassium concentration after training than before, and that moderate improvement of capacity to clear extracellular potassium during exercise may be due to increased activity of existing Na, K‐pumps in resting skeletal muscle fibres. This may reduce muscle fatigue, increase physical performance and explain the paradoxical observation that, despite an increased catecholamine response, there is a reduced risk of cardiac events after training.

    OriginalsprogEngelsk
    Sider (fra-til)642-647
    Antal sider6
    TidsskriftEuropean Journal of Clinical Investigation
    Vol/bind20
    Udgave nummer6
    DOI
    StatusUdgivet - dec. 1990

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