Evidence of an association between the Arg72 allele of the peptide YY and increased risk of type 2 diabetes

Signe S. Torekov*, Lesli H. Larsen, Charlotte Glümer, Knut Borch-Johnsen, Torben Jørgensen, Jens J. Holst, Ole D. Madsen, Torben Hansen, Oluf Pedersen

*Corresponding author af dette arbejde

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    Abstrakt

    We tested the hypothesis that variants in the gene encoding the prepropeptide YY (PYY) associate with type 2 diabetes and/or obesity. Mutation analyses of DNA from 84 patients with obesity and familial type 2 diabetes identified two polymorphisms, IVS3 + 68C>T and Arg72Thr, and one rare variant, +151C>A of PYY. The common allele of the Arg72Thr variant associated with type 2 diabetes with an allele frequency of the Arg allele of 0.667 (95% CI 0.658-0.677) among 4,639 glucose-tolerant subjects and 0.692 (0.674-0.710) among 1,326 patients with type 2 diabetes (P = 0.005, odds ratio 1.19 [95% CI 1.05-1.35]). The same polymorphism associated with overweight (25 ≤ BMI < 30 kg/m2) (P = 0.018, 1.15 [1.02-1.28]). In quantitative trait analyses of a population-based sample of 6,022 subjects, the Arg allele was associated with an increased plasma glucose level 2 h after an oral glucose tolerance test (OGTT) (P = 0.03), an increased area under the curve for the post-OGTT plasma glucose level (P = 0.03), and a lower insulinogenic index (P = 0.01). In conclusion, the common Arg allele of the PYY Arg72Thr variant modestly associates with type 2 diabetes and with type 2 diabetes-related quantitative traits.

    OriginalsprogEngelsk
    Sider (fra-til)2261-2265
    Antal sider5
    TidsskriftDiabetes
    Vol/bind54
    Udgave nummer7
    DOI
    StatusUdgivet - 1 jul. 2005

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