Endoscopic ultrasound for staging of colonic cancer proximal to the rectum: A systematic review and meta-analysis

Marie Louise Malmstrøm, Adrian Saftoiu, Peter Vilmann, Tobias Wirenfeldt Klausen, Ismail Gögenur

Publikation: Bidrag til tidsskriftReviewForskningpeer review

Abstrakt

Background and Objectives: Treatment of colonic cancer patients is highly dependent on the depth of tumor invasion (T-stage) as well as the extension of lymph node involvement (N-stage). We aimed to systematically review the accuracy of endoscopic ultrasound (EUS) for staging of colonic cancer proximal to the rectum. Patients and Methods: Men and women with colonic adenocarcinomas were included in the study. EUS staging was compared to histopathology as the gold standard. Outcome measures were T- and N-staging accuracies. Articles were searched in PubMed, Web of Science, The Cochrane Library, and EMBASE. Results: Six studies were identified comparing EUS staging of colonic cancer to histopathology. The pooled-staging sensitivity and specificity were 0.90 and 0.98 for T1 tumors, 0.67 and 0.96 for T2 tumors, and 0.97 and 0.83 for T3/T4 tumors, respectively. Sensitivity and specificity for N + disease were 0.59 and 0.78, respectively. Conclusions: EUS is a feasible method for T-staging of cancers of the colon proximal to the rectum. The accuracy of lymph node staging needs to be verified by prospective multicenter studies including larger patient populations.

OriginalsprogEngelsk
Sider (fra-til)307-314
Antal sider8
TidsskriftEndoscopic Ultrasound
Vol/bind5
Udgave nummer5
DOI
StatusUdgivet - 1 sep. 2016

Fingeraftryk Udforsk hvilke forskningsemner 'Endoscopic ultrasound for staging of colonic cancer proximal to the rectum: A systematic review and meta-analysis' indeholder.

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