Embryos are exposed to a significant drop in temperature during the embryo transfer procedure: a pilot study

Nick Macklon, Olga Delikari, Giuseppina Lamanna, Alison Campbell, Simon Fishel, Zaloa Larreategui Laiseca, Marcos Ferrando Serrano, Charlotte Coat, Peter Svalander

Publikation: Bidrag til tidsskriftArtikelForskningpeer review


RESEARCH QUESTION: During the embryo transfer procedure, to what degree of temperature drop are embryos exposed to between loading the transfer catheter and placing it into the uterus?

DESIGN: Twenty-nine simulated embryo transfer procedures were carried out across five clinics. A thermocouple probe was used for standardized measurements inside the embryo transfer catheter to investigate the change in temperature that occurred in the time period between loading and placing the catheter in the uterus.

RESULTS: In all cases, the temperature at the loaded catheter tip fell rapidly to ambient temperature during transit from the embryo transfer workstation in the laboratory to the procedure room, even though embryo transfer procedures, ambient temperatures and embryo transfer catheter temperatures at loading varied between clinics.

CONCLUSIONS: Given the sensitivity of the pre-implantation embryo to its immediate environment, the rapid and profound drop in temperature observed at the catheter tip that houses the embryo during transit from laboratory to the uterus may affect embryo viability and health. This issue should be addressed to ensure that the tight temperature control aimed for by IVF laboratories continues throughout the embryo transfer procedure, and could improve clinical outcomes.

Sider (fra-til)193-195
Antal sider3
TidsskriftReproductive BioMedicine Online
Udgave nummer2
Tidlig onlinedato25 maj 2021
StatusUdgivet - aug. 2021

Bibliografisk note

Copyright © 2021. Published by Elsevier Ltd.


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