Elevated transferrin saturation and risk of diabetes: Three population-based studies

Christina Ellervik, Thomas Mandrup-Poulsen, Henrik Ullits Andersen, Anne Tybjærg-Hansen, Merete Frandsen, Henrik Birgens, Børge G. Nordestgaard

Publikation: Bidrag til tidsskriftArtikelForskningpeer review

Abstrakt

OBJECTIVE - We tested the hypothesis that elevated transferrin saturation is associated with an increased risk of any form of diabetes, as well as type 1 or type 2 diabetes separately. RESEARCH DESIGN ANDMETHODS - We used two general population studies, The Copenhagen City Heart Study (CCHS, N = 9,121) and The Copenhagen General Population Study (CGPS, N = 24,195), as well as a 1:1 age- and sex-matched population-based case-control study with 6,129 patients with diabetes from the Steno Diabetes Centre and 6,129 control subjects, totaling 8,535 patients with diabetes and 37,039 control subjects. RESULTS - In the combined studies, odds ratios in those with transferrin saturation ≥50% vs. <50% were 2.1 (95% CI 1.3-3.4; P = 0.003) for any form of diabetes; 2.6 (1.2-5.6; P = 0.01) for type 1 diabetes; and 1.7 (1.4-2.1; P = 0.001) for type 2 diabetes. CONCLUSIONS - Elevated transferrin saturation confers a two- to threefold increased risk of developing any form of diabetes, as well as type 1 and type 2 diabetes separately.

OriginalsprogEngelsk
Sider (fra-til)2256-2258
Antal sider3
TidsskriftDiabetes Care
Vol/bind34
Udgave nummer10
DOI
StatusUdgivet - 1 okt. 2011

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