Effect on blood lipids, coagulation, and fibrinolysis of a fat high in myristic acid and a fat high in palmitic acid

Tine Tholstrup, Peter Marckmann, Jørgen Jespersen, Bengt Vessby, Aage Jart, Brittmarie Sandström

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review

    Abstrakt

    The hypothesis that myristic acid (C14:0) has a stronger cholesterol- increasing potential than does palmitic acid is based on very few experimental observations. A randomized, strictly controlled dietary study was therefore designed to investigate the effect of a synthetic fat that was high in myristic acid, and palm oil, which is high in palmitic acid, on lipoproteins and hemostatic variables. Twelve men were served two diets (40% of energy as fat) with 41% of fat as myristic (diet M) or palmitic acid (diet P) for 3 wk with 1 mo between the two dietary schedules. Plasma HDL cholesterol was 8% higher with diet M than with diet P: 1.10 ± 0.06 (x̄ ± SEM) vs 1.01 ± 0.05 mmol/L (P < 0.006). Diet M raised factor VII coagulant (F VIIc) activity to 98% (77-117%) vs 96% (71-109%) (medians and ranges) after diet P (P = 0.02). Total and LDL-cholesterol concentrations did not differ between the diets. In conclusion, the myristic acid test fat was not more cholesterolemic than was palm oil, but it did induce a minor rise in F VIIc activity.

    OriginalsprogEngelsk
    Sider (fra-til)919-925
    Antal sider7
    TidsskriftAmerican Journal of Clinical Nutrition
    Vol/bind60
    Udgave nummer6
    DOI
    StatusUdgivet - dec. 1994

    Fingeraftryk Udforsk hvilke forskningsemner 'Effect on blood lipids, coagulation, and fibrinolysis of a fat high in myristic acid and a fat high in palmitic acid' indeholder.

    Citationsformater