EFFECT OF THYROID FUNCTION ON NUMBER OF Na-K PUMPS IN HUMAN SKELETAL MUSCLE

K. Kjeldsen, C. O. G o tzsche, T. Clausen, A. N o rgaard, A. Thomassen

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    Abstrakt

    To evaluate the effect of thyroid function on the number of Na-K pumps in skeletal muscle, the number of 3H-ouabain binding sites was measured in biopsy specimens from the vastus lateralis muscle of euthyroid subjects and patients with hypothyroidism or hyperthyroidism. In hypothyroidism there was a decrease of 50% in 3H-ouabain binding sites, and in hyperthyroidism there was an increase of 68% in 3H-ouabain binding sites. When thyroid status became normal after treatment the number of 3H-ouabain binding sites also became normal. There were significant correlations between several thyroid function tests and the number of 3H-ouabain binding sites. Free T4-index gave the highest r value (0·87). These changes may account for the variations in digitalis sensitivity associated with thyroid disorders.

    OriginalsprogEngelsk
    Sider (fra-til)8-10
    Antal sider3
    TidsskriftThe Lancet
    Vol/bind324
    Udgave nummer8393
    DOI
    StatusUdgivet - 7 jul. 1984

    Fingeraftryk Udforsk hvilke forskningsemner 'EFFECT OF THYROID FUNCTION ON NUMBER OF Na-K PUMPS IN HUMAN SKELETAL MUSCLE' indeholder.

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