Effect of omeprazole and cimetidine on prepyloric gastric ulcer: Double blind comparative trial

K. Lauritsen, S. J. Rune, H. R. Wulff, J. H. Olsen, L. S. Laursen, T. Havelund, L. Astrup, F. Bendtsen, J. Linde, P. Bytzer, U. Tage-Jensen, C. Gluud, H. H. Andersen, P. Schlichting, H. Skovbjerg, A. Mertz-Nielsen, J. Rask-Madsen

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    Abstract

    We conducted a six week double blind randomised study of 176 patients with prepyloric gastric ulcer to determine whether the proton pump inhibitor, omeprazole 30 mg daily would accelerate healing and pain relief, as compared with cimetidine 1 g daily. At two, four, and six weeks after entry ulcers healed in a larger percentage of patients treated with omeprazole (54, 81, and 86%) than of those treated with cimetidine (39, 73, and 78%) ('intention to treat' cohort; p<0.05 at two weeks). A higher proportion of patients on omeprazole became free of pain during the first week of treatment (p<0.05). No major clinical or biochemical side effects were noted. Omeprazole is an efficient treatment for patients with prepyloric gastric ulcers.

    OriginalsprogEngelsk
    Sider (fra-til)249-253
    Antal sider5
    TidsskriftGut
    Vol/bind29
    Udgave nummer2
    DOI
    StatusUdgivet - 1 jan. 1988

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