Effect of liraglutide on myocardial glucose uptake and blood flow in stable chronic heart failure patients: A double-blind, randomized, placebo-controlled LIVE sub-study

Roni Nielsen, Anders Jorsal, Peter Iversen, Lars Poulsen Tolbod, Kirsten Bouchelouche, Jens Sørensen, Hendrik Johannes Harms, Allan Flyvbjerg, Lise Tarnow, Caroline Kistorp, Ida Gustafsson, Hans Erik Bøtker, Henrik Wiggers

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review

    Abstrakt

    Background: The glucagon-like peptide-1 analog liraglutide increases heart rate and may be associated with more cardiac events in chronic heart failure (CHF) patients. We studied whether this could be ascribed to effects on myocardial glucose uptake (MGU), myocardial blood flow (MBF) and MBF reserve (MFR). Methods and Results: CHF patients with left ventricular ejection fraction ≤45% and without type 2 diabetes were randomized to liraglutide (N = 18) 1.8 mg once daily or placebo (N = 18) for 24 weeks in a double-blinded design. Changes in MGU during an oral glucose tolerance test (OGTT) and changes in MBF and MFR from baseline to follow-up were measured quantitatively by 18 F-FDG and 15 O-H 2 O positron emission tomography. Compared with placebo, liraglutide reduced weight (P = 0.03), HbA1c (P = 0.03) and the 2-hour glucose value during the OGTT (P = 0.004). Despite this, changes in MGU (P = 0.98), MBF (P = 0.76) and MFR (P = 0.89) from baseline to follow-up did not differ between groups. Furthermore, there was no association between the level of insulin resistance at baseline and changes in MGU in patients treated with liraglutide. Conclusion: Liraglutide did not affect MGU, MBF, or MFR in non-diabetic CHF patients. Any potential increase in cardiac events in these patients seems not to involve changes in MGU, MBF, or MFR. Trial Registration: Trial registry: http://www.ClinicalTrials.org. Identifier: NCT01472640. Url: https://clinicaltrials.gov/ct2/show/NCT01472640?term=NCT01472640&rank=1.

    OriginalsprogEngelsk
    Sider (fra-til)585-597
    Antal sider13
    TidsskriftJournal of Nuclear Cardiology
    Vol/bind26
    Udgave nummer2
    DOI
    StatusUdgivet - 15 apr. 2019

    Fingeraftryk Udforsk hvilke forskningsemner 'Effect of liraglutide on myocardial glucose uptake and blood flow in stable chronic heart failure patients: A double-blind, randomized, placebo-controlled LIVE sub-study' indeholder.

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