Effect of Intracoronary and Intravenous Melatonin on Myocardial Salvage Index in Patients with ST-Elevation Myocardial Infarction: a Randomized Placebo Controlled Trial

Sarah Ekeloef, Natalie Halladin, Siv Fonnes, Svend Eggert Jensen, Tomas Zaremba, Jacob Rosenberg, Grete Jonsson, Jens Aarøe, Lærke Smidt Gasbjerg, Mette Marie Rosenkilde, Ismail Gögenur

Publikation: Bidrag til tidsskriftArtikelForskningpeer review

Abstrakt

Melatonin has attenuated myocardial ischemia reperfusion injury in experimental studies. We hypothesized that the administration of melatonin during acute myocardial reperfusion improves myocardial salvage index in patients with ST-elevation myocardial infarction. Patients (n = 48) were randomized in a 1:1 ratio to intracoronary and intravenous melatonin (total 50 mg) or placebo. The myocardial salvage index assessed by cardiac magnetic resonance imaging at day 4 (± 1 day) after primary percutaneous coronary intervention was similar in the melatonin group (n = 22) at 55.3% (95% CI 47.0–63.6) and the placebo group (n = 19) at 61.5% (95% CI 57.5–65.5), p = 0.21. The levels of high-sensitive troponin T, creatinine kinase myocardial band, and oxidative biomarkers (advanced oxidation protein products, malondialdehyde, myeloperoxidase) were similar in the groups. The frequency of clinical events at 90 days did not differ between the groups. In conclusion, melatonin did not improve the myocardial salvage index after primary percutaneous coronary intervention in patients with ST elevation myocardial infarction compared with placebo.

OriginalsprogEngelsk
Sider (fra-til)470-479
Antal sider10
TidsskriftJournal of Cardiovascular Translational Research
Vol/bind10
Udgave nummer5-6
DOI
StatusUdgivet - 1 dec. 2017

Fingeraftryk Udforsk hvilke forskningsemner 'Effect of Intracoronary and Intravenous Melatonin on Myocardial Salvage Index in Patients with ST-Elevation Myocardial Infarction: a Randomized Placebo Controlled Trial' indeholder.

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