Effect of High Inspiratory Oxygen Fraction on Endothelial Function in Healthy Volunteers: A Randomized Controlled Crossover Pilot Study

Mikkel Hjordt Holm Larsen*, Sarah Ekeloef, Dunja Kokotovic, Anne Marie Schou-Pedersen, Jens Lykkesfeldt, Ismail Gögenür

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftReviewForskningpeer review

Abstrakt

It has been suggested that high inspiratory oxygen concentrations during anesthesia may be associated with higher postoperative mortality due to endothelial dysfunction. A randomized controlled crossover study was conducted with 25 healthy male volunteers. They inhaled an oxygen concentration of 30% and 80%. The endothelial function was assessed using noninvasive digital pulse amplitude tonometry (EndoPAT) supported by endothelial biomarkers. The difference in endothelial function between the 2 treatments was 0.05 (95% confidence interval,-0.36 to 0.27; P =.77). Endothelial biomarkers were unaffected. Inhalation of a high oxygen fraction in healthy volunteers did not result in a significant reduction of endothelial function.

OriginalsprogEngelsk
Sider (fra-til)1793-1796
Antal sider4
TidsskriftAnesthesia and Analgesia
Vol/bind125
Udgave nummer5
DOI
StatusUdgivet - 1 nov. 2017

Fingeraftryk

Udforsk hvilke forskningsemner 'Effect of High Inspiratory Oxygen Fraction on Endothelial Function in Healthy Volunteers: A Randomized Controlled Crossover Pilot Study' indeholder.

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