EEG with extreme delta brush in young female with methotrexate neurotoxicity supports NMDA receptor involvement

Lisbeth Samsø Schmidt, Troels W. Kjær, Kjeld Schmiegelow, Alfred Peter Born

Publikation: Bidrag til tidsskriftArtikelForskningpeer review

Abstrakt

Sub-acute neurotoxicity is a well-known complication to high-dose and intrathecal methotrexate (MTX) treatment of children with leukemia. Symptoms can be treated safely by dextromethorphan, a non-competitive antagonist to N-methyl-D-aspartic acid receptor (NMDAR). In a female with subacute MTX neurotoxicity, we observed an electroencephalographic (EEG) with extreme delta brush. Extreme delta brush is an EEG pattern previously described in patients with NMDAR autoimmune encephalitis. The observations suggest that the mechanism of this neurotoxicity may be mediated by the NMDAR. Furthermore, extreme EEG delta brush should suggest a diagnosis of MTX associated subacute neurotoxicity.

OriginalsprogEngelsk
Sider (fra-til)795-797
Antal sider3
TidsskriftEuropean Journal of Paediatric Neurology
Vol/bind21
Udgave nummer5
DOI
StatusUdgivet - sep. 2017

Fingeraftryk Udforsk hvilke forskningsemner 'EEG with extreme delta brush in young female with methotrexate neurotoxicity supports NMDA receptor involvement' indeholder.

Citationsformater