Echocardiographic abnormalities and predictors of mortality in hospitalized COVID-19 patients: the ECHOVID-19 study

Mats Christian Højbjerg Lassen, Kristoffer Grundtvig Skaarup, Jannie Nørgaard Lind, Alia Saed Alhakak, Morten Sengeløv, Anne Bjerg Nielsen, Caroline Espersen, Kirstine Ravnkilde, Raphael Hauser, Liv Borum Schöps, Eva Holt, Niklas Dyrby Johansen, Daniel Modin, Kasper Djernaes, Claus Graff, Henning Bundgaard, Christian Hassager, Reza Jabbari, Jørn Carlsen, Anne-Mette LebechOle Kirk, Uffe Bodtger, Matias Greve Lindholm, Gowsini Joseph, Lothar Wiese, Frank Vinholt Schiødt, Ole Peter Kristiansen, Emil Schwarz Walsted, Olav Wendelboe Nielsen, Birgitte Lindegaard Madsen, Niels Tønder, Thomas Benfield, Klaus Nielsen Jeschke, Charlotte Suppli Ulrik, Filip Knop, Morten Lamberts, Pradeesh Sivapalan, Gunnar Gislason, Jacob Louis Marott, Rasmus Møgelvang, Gorm Jensen, Peter Schnohr, Peter Søgaard, Scott D Solomon, Kasper Iversen, Jens Ulrik Staehr Jensen, Morten Schou, Tor Biering-Sørensen

Publikation: Bidrag til tidsskriftArtikelForskningpeer review

Abstrakt

AIMS: The present study had two aims: (i) compare echocardiographic parameters in COVID-19 patients with matched controls and (2) assess the prognostic value of measures of left (LV) and right ventricular (RV) function in relation to COVID-19 related death.

METHODS AND RESULTS: In this prospective multicentre cohort study, 214 consecutive hospitalized COVID-19 patients underwent an echocardiographic examination (by pre-determined research protocol). All participants were successfully matched 1:1 with controls from the general population on age, sex, and hypertension. Mean age of the study sample was 69 years, and 55% were male participants. LV and RV systolic function was significantly reduced in COVID-19 cases as assessed by global longitudinal strain (GLS) (16.4% ± 4.3 vs. 18.5% ± 3.0, P < 0.001), tricuspid annular plane systolic excursion (TAPSE) (2.0 ± 0.4 vs. 2.6 ± 0.5, P < 0.001), and RV strain (19.8 ± 5.9 vs. 24.2 ± 6.5, P = 0.004). All parameters remained significantly reduced after adjusting for important cardiac risk factors. During follow-up (median: 40 days), 25 COVID-19 cases died. In multivariable Cox regression reduced TAPSE [hazard ratio (HR) = 1.18, 95% confidence interval (CI) [1.07-1.31], P = 0.002, per 1 mm decrease], RV strain (HR = 1.64, 95%CI[1.02;2.66], P = 0.043, per 1% decrease) and GLS (HR = 1.20, 95%CI[1.07-1.35], P = 0.002, per 1% decrease) were significantly associated with COVID-19-related death. TAPSE and GLS remained significantly associated with the outcome after restricting the analysis to patients without prevalent heart disease.

CONCLUSIONS: RV and LV function are significantly impaired in hospitalized COVID-19 patients compared with matched controls. Furthermore, reduced TAPSE and GLS are independently associated with COVID-19-related death.

OriginalsprogEngelsk
Sider (fra-til)4189-4197
TidsskriftESC Heart Failure
Vol/bind7
Udgave nummer6
Tidlig onlinedato22 okt. 2020
DOI
StatusUdgivet - dec. 2020

Fingeraftryk Udforsk hvilke forskningsemner 'Echocardiographic abnormalities and predictors of mortality in hospitalized COVID-19 patients: the ECHOVID-19 study' indeholder.

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