TY - JOUR
T1 - ECG as a first step in the detection of left ventricular systolic dysfunction in the elderly
AU - Olesen, Line Lisbeth
AU - Andersen, Andreas
PY - 2016
Y1 - 2016
N2 - Aims Due to the demographic development there is an increasing number of senior citizens with left ventricular systolic dysfunction (LVSD), defined as ejection fraction (EF) < 40%. Unfortunately there are under-diagnosis and under-treatment in the
elderly of this serious condition. Echocardiography is the gold standard to diagnose LVSD, but access is limited. Simple screening methods may ensure reduction of undetected cases, and this study investigates if electrocardiogram (ECG) can be used to
screen for LVSD in the geriatric population.
Methods and results A total of 260 persons aged 75 to 92 years had an echocardiography, a 12 leads ECG, and NT-proBNP;
61 had EF < 40%, and of these 60 had an abnormal ECG. EF < 40% was significantly related to atrial fibrillation (A), pacing (P),
LBBB (L), Q-waves (Q), and QRS duration ≥ 120 ms (D). EF < 40%, atrial fibrillation, pacing, and LBBB were related to
NT-proBNP > 35 pmol/L. When APL was absent, NT-proBNP had discriminatory value regarding LVSD in the presence
of Q-waves or QRS duration > 120 ms. Algorithms to screen for LVSD had sensitivity >90% and specificity >80%
and claimed at least one of five (A/P/L/Q/D), one of 4 (A/P/L/Q), or one of three (A/Q/D) ECG changes. The optimal
algorithm to reduce the need for diagnostic echocardiographies included four (A/P/L/Q) ECG changes and measurement of NT-proBNP when Q-waves were the only ECG change present.
Conclusions Ninety percent of LVSD may be detected, and when there is atrial fibrillation, pacing or LBBB, or QRS ≥ 120 ms/
Q-waves and NT-proBNP>35 pmol/L, a diagnostic echocardiography should be considered.
AB - Aims Due to the demographic development there is an increasing number of senior citizens with left ventricular systolic dysfunction (LVSD), defined as ejection fraction (EF) < 40%. Unfortunately there are under-diagnosis and under-treatment in the
elderly of this serious condition. Echocardiography is the gold standard to diagnose LVSD, but access is limited. Simple screening methods may ensure reduction of undetected cases, and this study investigates if electrocardiogram (ECG) can be used to
screen for LVSD in the geriatric population.
Methods and results A total of 260 persons aged 75 to 92 years had an echocardiography, a 12 leads ECG, and NT-proBNP;
61 had EF < 40%, and of these 60 had an abnormal ECG. EF < 40% was significantly related to atrial fibrillation (A), pacing (P),
LBBB (L), Q-waves (Q), and QRS duration ≥ 120 ms (D). EF < 40%, atrial fibrillation, pacing, and LBBB were related to
NT-proBNP > 35 pmol/L. When APL was absent, NT-proBNP had discriminatory value regarding LVSD in the presence
of Q-waves or QRS duration > 120 ms. Algorithms to screen for LVSD had sensitivity >90% and specificity >80%
and claimed at least one of five (A/P/L/Q/D), one of 4 (A/P/L/Q), or one of three (A/Q/D) ECG changes. The optimal
algorithm to reduce the need for diagnostic echocardiographies included four (A/P/L/Q) ECG changes and measurement of NT-proBNP when Q-waves were the only ECG change present.
Conclusions Ninety percent of LVSD may be detected, and when there is atrial fibrillation, pacing or LBBB, or QRS ≥ 120 ms/
Q-waves and NT-proBNP>35 pmol/L, a diagnostic echocardiography should be considered.
M3 - Article
C2 - 27774266
SN - 2055-5822
VL - 3
SP - 44
EP - 52
JO - ESC heart failure
JF - ESC heart failure
ER -