Early reperfusion assessment and repeated thrombolysis in acute myocardial infarction estimated by repeated standard electrocardiography: A randomised, double-blind, placebo-controlled pilot study

Sabine Gill*, Benedikte Haastrup, Torben Haghfelt, Mikael Dellborg, Peter M. Clemmensen

*Corresponding author af dette arbejde

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review

    Abstract

    Thrombolytic therapy with streptokinase (SK) in acute myocardial infarction (AMI) does not result in early reperfusion in approximately 25% of patients. We hypothesized that early repeated thrombolysis with rt-PA in patients with early failed reperfusion would result in myocardial reperfusion. Fifty-nine AMI patients with a symptom delay of <6 h, treated with SK were included. ECG was taken on admission and after 90 and 180 min. An ST recovery of ≥ 625% at 90 min was interpreted as successful reperfusion. Sixteen patients had failed reperfusion at 90 min and were randomized to repeated thrombolysis with rt-PA or placebo. At 180 min from SK start, ST recovery was higher in the placebo group than in the rt-PA group (71 vs. 40%, p = 0.05). No serious bleeding complications were observed. Due to the limited sample size it was not possible to draw prominent conclusions. (C) 2000 S. Karger AG, Basel.

    OriginalsprogEngelsk
    Sider (fra-til)58-65
    Antal sider8
    TidsskriftCardiology
    Vol/bind94
    Udgave nummer1
    DOI
    StatusUdgivet - 1 jan. 2000

    Fingeraftryk

    Udforsk hvilke forskningsemner 'Early reperfusion assessment and repeated thrombolysis in acute myocardial infarction estimated by repeated standard electrocardiography: A randomised, double-blind, placebo-controlled pilot study' indeholder.

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