TY - JOUR
T1 - Dyspepsia as an adverse effect of drugs
AU - Bytzer, Peter
PY - 2010/4/1
Y1 - 2010/4/1
N2 - Drugs are frequently implicated as a possible cause in new onset dyspeptic symptoms and few drugs are free of this suspicion. Nausea, anorexia, abdominal pain and dyspepsia make up between one-tenth and one-third of reported adverse reactions but they are all so common, both in the background population and among patients, that they are frequently attributed to an illness rather than to medications. No symptom or clinical sign is pathognomonic for adverse drug effects, maybe with the exception of vomiting. Dyspepsia is a common reporting in placebo-arms of treatment trials. Owing to the high background incidence of dyspepsia, it is difficult to discern between spontaneous and true drug-related dyspepsia. The mechanisms by which a drug causes dyspepsia are often unknown even though some drugs are known to cause direct mucosal injury. Non-steroidal anti-inflammatory drugs and antibiotics are common causes of drug-related dyspepsia.
AB - Drugs are frequently implicated as a possible cause in new onset dyspeptic symptoms and few drugs are free of this suspicion. Nausea, anorexia, abdominal pain and dyspepsia make up between one-tenth and one-third of reported adverse reactions but they are all so common, both in the background population and among patients, that they are frequently attributed to an illness rather than to medications. No symptom or clinical sign is pathognomonic for adverse drug effects, maybe with the exception of vomiting. Dyspepsia is a common reporting in placebo-arms of treatment trials. Owing to the high background incidence of dyspepsia, it is difficult to discern between spontaneous and true drug-related dyspepsia. The mechanisms by which a drug causes dyspepsia are often unknown even though some drugs are known to cause direct mucosal injury. Non-steroidal anti-inflammatory drugs and antibiotics are common causes of drug-related dyspepsia.
KW - Adverse events
KW - Drugs
KW - Dyspepsia
KW - Medications
KW - Pharmaco-epidemiology
KW - Side effects
UR - http://www.scopus.com/inward/record.url?scp=77749343039&partnerID=8YFLogxK
U2 - 10.1016/j.bpg.2009.11.006
DO - 10.1016/j.bpg.2009.11.006
M3 - Article
C2 - 20227025
AN - SCOPUS:77749343039
VL - 24
SP - 109
EP - 120
JO - Bailliere's Best Practice and Research in Clinical Gastroenterology
JF - Bailliere's Best Practice and Research in Clinical Gastroenterology
SN - 1521-6918
IS - 2
ER -