Discriminating Between IDA and ACD using TfR as Indikators of Iron Status an oxydative balance

Publikation: Bidrag til tidsskriftKonferenceartikelForskning


The concentrations of the TfR (soluble receptor for transferrin) positively correlated with total mass of tissue receptors, increased in response to a deficiency of iron and, conversely, negatively correlated with the content of cellular iron. Methods: Blood was collected from children with iron/nutritive deficient anemia,(n=20), IDA group, from children with inflammations and/ or recurrent infections (n=53) with anemia syndrome, ACD group, and from healthy controls (n=19). Serum concentrations of soluble transferrin receptor were determined using the QuantikineIVD Human immunoassay kit (R&D Systems) in nmol/l. Plasma nitric oxide (NO) concentration was measured by Cayman Chemical′s photometric test (μmol/L). Results: The TfR concentration was increased (mean ± SD), 52,48 ± 21,36 in IDA patients, and was normal (29,67 ± 3,81) in controls and for more than 55% of the ACD patients (20,4±8). The TfR/log ferritin was significantly low (p< 0.001) in the ACD group, 11,82±5,68 compared to IDA (55,46±33,16) and controls (24,40±3,49),while NO value were extremely high in the ACD group: 123±41 vs IDA 70±49; Control 49±12. Conclusion: The determination of sTfR is necessary in the differential diagnosis of these two anemias. One explanation proposed for this inadequate sTfR secretion is that the anemia is adaptive; to reflects a reduced rate of oxygen use by tissues in response to increased oxidative stress induced by pro-inflammatory state of the organism. One colorful description of this process is that the "hematologic thermostat has been turned down a bit".
Sider (fra-til)402
Antal sider1
TidsskriftEuropean Journal of Immunology
Udgave nummerSuppl. 1
StatusUdgivet - 1 aug. 2016
Udgivet eksterntJa
BegivenhedInternational Congress of Immunology - Melbourne, Australien
Varighed: 21 aug. 201626 aug. 2016
Konferencens nummer: 2013