Discovery and refinement of loci associated with lipid levels

C. J. Willer; E. M. Schmidt; S. Sengupta; G. M. Peloso; S. Gustafsson; S. Kanoni; A. Ganna; J. Chen; M. L. Buchkovich; S. Mora; J. S. Beckmann; J. L. Bragg-Gresham; H. Y. Chang; A. Demirkan; H. M. Den Hertog; R. Do; L. A. Donnelly; G. B. Ehret; T. Esko; M. F. Feitosa; T. Ferreira; K. Fischer; P. Fontanillas; R. M. Fraser; D. F. Freitag; D. Gurdasani; K. Heikkila; E. Hypponen; A. Isaacs; A. U. Jackson; A. Johansson; T. Johnson; M. Kaakinen; J. Kettunen; M. E. Kleber; X. H. Li; J. A. Luan; L. P. Lyytikainen; P. K. E. Magnusson; M. Mangino; E. Mihailov; M. E. Montasser; M. Muller-Nurasyid; I. M. Nolte; J. R. O'Connell; C. D. Palmer; M. Perola; A. K. Petersen; S. Sanna; R. Saxena; S. K. Service; S. Shah; D. Shungin; C. Sidore; C. Song; R. J. Strawbridge; I. Surakka; T. Tanaka; T. M. Teslovich; G. Thorleifsson; E. G. Van den Herik; B. F. Voight; K. A. Volcik; L. L. Waite; A. Wong; Y. Wu; W. H. Zhang; D. Absher; G. Asiki; I. Barroso; L. F. Been; J. L. Bolton; L. L. Bonnycastle; P. Brambilla; M. S. Burnett; G. Cesana; M. Dimitriou; A. S. F. Doney; A. Doring; P. Elliott; S. E. Epstein; G. I. Eyjolfsson; B. Gigante; M. O. Goodarzi; H. Grallert; M. L. Gravito; C. J. Groves; G. Hallmans; A. L. Hartikainen; C. Hayward; D. Hernandez; A. A. Hicks; H. Holm; Y. J. Hung; T. Illig; M. R. Jones; P. Kaleebu; J. J. P. Kastelein; K. T. Khaw; E. Kim; N. Klopp; P. Komulainen; M. Kumari; C. Langenberg; T. Lehtimaki; S. Y. Lin; J. Lindstrom; R. J. F. Loos; F. Mach; W. L. McArdle; C. Meisinger; B. D. Mitchell; G. Muller; R. Nagaraja; N. Narisu; T. V. M. Nieminen; R. N. Nsubuga; I. Olafsson; K. K. Ong; A. Palotie; T. Papamarkou; C. Pomilla; A. Pouta; D. J. Rader; M. P. Reilly; P. M. Ridker; F. Rivadeneira; I. Rudan; A. Ruokonen; N. Samani; H. Scharnagl; J. Seeley; K. Silander; A. Stancakova; K. Stirrups; A. J. Swift; L. Tiret; A. G. Uitterlinden; L. J. van Pelt; S. Vedantam; N. Wainwright; C. Wijmenga; S. H. Wild; G. Willemsen; T. Wilsgaard; J. F. Wilson; E. H. Young; J. H. Zhao; L. S. Adair; D. Arveiler; T. L. Assimes; S. Bandinelli; F. Bennett; M. Bochud; B. O. Boehm; D. I. Boomsma; I. B. Borecki; S. R. Bornstein; P. Bovet; M. Burnier; H. Campbell; A. Chakravarti; J. C. Chambers; Y. D. I. Chen; F. S. Collins; R. S. Cooper; J. Danesh; G. Dedoussis; U. de Faire; A. B. Feranil; J. Ferrieres; L. Ferrucci; N. B. Freimer; C. Gieger; L. C. Groop; V. Gudnason; U. Gyllensten; A. Hamsten; T. B. Harris; A. Hingorani; J. N. Hirschhorn; A. Hofman; G. K. Hovingh; C. A. Hsiung; S. E. Humphries; S. C. Hunt; K. Hveem; C. Iribarren; M. R. Jarvelin; A. Jula; M. Kahonen; J. Kaprio; A. Kesaniemi; M. Kivimaki; J. S. Kooner; P. J. Koudstaal; R. M. Krauss; D. Kuh; J. Kuusisto; K. O. Kyvik; M. Laakso; T. A. Lakka; L. Lind; C. M. Lindgren; N. G. Martin; W. Marz; M. I. McCarthy; C. A. McKenzie; P. Meneton; A. Metspalu; L. Moilanen; A. D. Morris; P. B. Munroe; I. Njolstad; N. L. Pedersen; C. Power; P. P. Pramstaller; J. F. Price; B. M. Psaty; T. Quertermous; R. Rauramaa; D. Saleheen; V. Salomaa; D. K. Sanghera; J. Saramies; P. E. H. Schwarz; W. H. H. Sheu; A. R. Shuldiner; A. Siegbahn; T. D. Spector; K. Stefansson; D. P. Strachan; B. O. Tayo; E. Tremoli; J. Tuomilehto; M. Uusitupa; C. M. van Duijn; P. Vollenweider; L. Wallentin; N. J. Wareham; J. B. Whitfield; B. H. R. Wolffenbuttel; J. M. Ordovas; E. Boerwinkle; C. N. A. Palmer; U. Thorsteinsdottir; D. I. Chasman; J. I. Rotter; P. W. Franks; S. Ripatti; L. A. Cupples; M. S. Sandhu; S. S. Rich; M. Boehnke; P. Deloukas; S. Kathiresan; K. L. Mohlke; E. Ingelsson; G. R. Abecasis; Consortium Global Lipids Genetics

doi:10.1038/ng.2797

Discovery and refinement of loci associated with lipid levels

C. J. Willer, E. M. Schmidt, S. Sengupta, G. M. Peloso, S. Gustafsson, S. Kanoni, A. Ganna, J. Chen, M. L. Buchkovich, S. Mora, J. S. Beckmann, J. L. Bragg-Gresham, H. Y. Chang, A. Demirkan, H. M. Den Hertog, R. Do, L. A. Donnelly, G. B. Ehret, T. Esko, M. F. FeitosaT. Ferreira, K. Fischer, P. Fontanillas, R. M. Fraser, D. F. Freitag, D. Gurdasani, K. Heikkila, E. Hypponen, A. Isaacs, A. U. Jackson, A. Johansson, T. Johnson, M. Kaakinen, J. Kettunen, M. E. Kleber, X. H. Li, J. A. Luan, L. P. Lyytikainen, P. K. E. Magnusson, M. Mangino, E. Mihailov, M. E. Montasser, M. Muller-Nurasyid, I. M. Nolte, J. R. O'Connell, C. D. Palmer, M. Perola, A. K. Petersen, S. Sanna, R. Saxena, S. K. Service, S. Shah, D. Shungin, C. Sidore, C. Song, R. J. Strawbridge, I. Surakka, T. Tanaka, T. M. Teslovich, G. Thorleifsson, E. G. Van den Herik, B. F. Voight, K. A. Volcik, L. L. Waite, A. Wong, Y. Wu, W. H. Zhang, D. Absher, G. Asiki, I. Barroso, L. F. Been, J. L. Bolton, L. L. Bonnycastle, P. Brambilla, M. S. Burnett, G. Cesana, M. Dimitriou, A. S. F. Doney, A. Doring, P. Elliott, S. E. Epstein, G. I. Eyjolfsson, B. Gigante, M. O. Goodarzi, H. Grallert, M. L. Gravito, C. J. Groves, G. Hallmans, A. L. Hartikainen, C. Hayward, D. Hernandez, A. A. Hicks, H. Holm, Y. J. Hung, T. Illig, M. R. Jones, P. Kaleebu, J. J. P. Kastelein, K. T. Khaw, E. Kim, N. Klopp, P. Komulainen, M. Kumari, C. Langenberg, T. Lehtimaki, S. Y. Lin, J. Lindstrom, R. J. F. Loos, F. Mach, W. L. McArdle, C. Meisinger, B. D. Mitchell, G. Muller, R. Nagaraja, N. Narisu, T. V. M. Nieminen, R. N. Nsubuga, I. Olafsson, K. K. Ong, A. Palotie, T. Papamarkou, C. Pomilla, A. Pouta, D. J. Rader, M. P. Reilly, P. M. Ridker, F. Rivadeneira, I. Rudan, A. Ruokonen, N. Samani, H. Scharnagl, J. Seeley, K. Silander, A. Stancakova, K. Stirrups, A. J. Swift, L. Tiret, A. G. Uitterlinden, L. J. van Pelt, S. Vedantam, N. Wainwright, C. Wijmenga, S. H. Wild, G. Willemsen, T. Wilsgaard, J. F. Wilson, E. H. Young, J. H. Zhao, L. S. Adair, D. Arveiler, T. L. Assimes, S. Bandinelli, F. Bennett, M. Bochud, B. O. Boehm, D. I. Boomsma, I. B. Borecki, S. R. Bornstein, P. Bovet, M. Burnier, H. Campbell, A. Chakravarti, J. C. Chambers, Y. D. I. Chen, F. S. Collins, R. S. Cooper, J. Danesh, G. Dedoussis, U. de Faire, A. B. Feranil, J. Ferrieres, L. Ferrucci, N. B. Freimer, C. Gieger, L. C. Groop, V. Gudnason, U. Gyllensten, A. Hamsten, T. B. Harris, A. Hingorani, J. N. Hirschhorn, A. Hofman, G. K. Hovingh, C. A. Hsiung, S. E. Humphries, S. C. Hunt, K. Hveem, C. Iribarren, M. R. Jarvelin, A. Jula, M. Kahonen, J. Kaprio, A. Kesaniemi, M. Kivimaki, J. S. Kooner, P. J. Koudstaal, R. M. Krauss, D. Kuh, J. Kuusisto, K. O. Kyvik, M. Laakso, T. A. Lakka, L. Lind, C. M. Lindgren, N. G. Martin, W. Marz, M. I. McCarthy, C. A. McKenzie, P. Meneton, A. Metspalu, L. Moilanen, A. D. Morris, P. B. Munroe, I. Njolstad, N. L. Pedersen, C. Power, P. P. Pramstaller, J. F. Price, B. M. Psaty, T. Quertermous, R. Rauramaa, D. Saleheen, V. Salomaa, D. K. Sanghera, J. Saramies, P. E. H. Schwarz, W. H. H. Sheu, A. R. Shuldiner, A. Siegbahn, T. D. Spector, K. Stefansson, D. P. Strachan, B. O. Tayo, E. Tremoli, J. Tuomilehto, M. Uusitupa, C. M. van Duijn, P. Vollenweider, L. Wallentin, N. J. Wareham, J. B. Whitfield, B. H. R. Wolffenbuttel, J. M. Ordovas, E. Boerwinkle, C. N. A. Palmer, U. Thorsteinsdottir, D. I. Chasman, J. I. Rotter, P. W. Franks, S. Ripatti, L. A. Cupples, M. S. Sandhu, S. S. Rich, M. Boehnke, P. Deloukas, S. Kathiresan, K. L. Mohlke, E. Ingelsson, G. R. Abecasis, Consortium Global Lipids Genetics

Publikation: Bidrag til tidsskrift › Artikel › Forskning › peer review

Abstract

Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P

Originalsprog	Engelsk
Sider (fra-til)	1274-1283
Antal sider	10
Tidsskrift	Nature Genetics
Vol/bind	45
DOI	https://doi.org/10.1038/ng.2797
Status	Udgivet - 2013

Adgang til dokumentet

10.1038/ng.2797

Citationsformater

Willer, C. J., Schmidt, E. M., Sengupta, S., Peloso, G. M., Gustafsson, S., Kanoni, S., Ganna, A., Chen, J., Buchkovich, M. L., Mora, S., Beckmann, J. S., Bragg-Gresham, J. L., Chang, H. Y., Demirkan, A., Den Hertog, H. M., Do, R., Donnelly, L. A., Ehret, G. B., Esko, T., ... Global Lipids Genetics, C. (2013). Discovery and refinement of loci associated with lipid levels. Nature Genetics, 45, 1274-1283. https://doi.org/10.1038/ng.2797

@article{e4532691727d4ba98150c74f2431dc0b,

title = "Discovery and refinement of loci associated with lipid levels",

abstract = "Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P ",

keywords = "CORONARY-ARTERY-DISEASE DENSITY-LIPOPROTEIN CHOLESTEROL GENOME-WIDE ASSOCIATION HEART-DISEASE CARDIOVASCULAR-DISEASE SUSCEPTIBILITY LOCI IDENTIFIES 13 RISK GENE METAANALYSIS, Cholesterol, LDL/blood, European Continental Ancestry Group/genetics, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, African Continental Ancestry Group/genetics, Genotype, Asian Continental Ancestry Group/genetics, HDL/blood, Triglycerides/blood, Lipids/blood, Coronary Artery Disease/blood",

author = "Willer, \{C. J.\} and Schmidt, \{E. M.\} and S. Sengupta and Peloso, \{G. M.\} and S. Gustafsson and S. Kanoni and A. Ganna and J. Chen and Buchkovich, \{M. L.\} and S. Mora and Beckmann, \{J. S.\} and Bragg-Gresham, \{J. L.\} and Chang, \{H. Y.\} and A. Demirkan and \{Den Hertog\}, \{H. M.\} and R. Do and Donnelly, \{L. A.\} and Ehret, \{G. B.\} and T. Esko and Feitosa, \{M. F.\} and T. Ferreira and K. Fischer and P. Fontanillas and Fraser, \{R. M.\} and Freitag, \{D. F.\} and D. Gurdasani and K. Heikkila and E. Hypponen and A. Isaacs and Jackson, \{A. U.\} and A. Johansson and T. Johnson and M. Kaakinen and J. Kettunen and Kleber, \{M. E.\} and Li, \{X. H.\} and Luan, \{J. A.\} and Lyytikainen, \{L. P.\} and Magnusson, \{P. K. E.\} and M. Mangino and E. Mihailov and Montasser, \{M. E.\} and M. Muller-Nurasyid and Nolte, \{I. M.\} and O'Connell, \{J. R.\} and Palmer, \{C. D.\} and M. Perola and Petersen, \{A. K.\} and S. Sanna and R. Saxena and Service, \{S. K.\} and S. Shah and D. Shungin and C. Sidore and C. Song and Strawbridge, \{R. J.\} and I. Surakka and T. Tanaka and Teslovich, \{T. M.\} and G. Thorleifsson and \{Van den Herik\}, \{E. G.\} and Voight, \{B. F.\} and Volcik, \{K. A.\} and Waite, \{L. L.\} and A. Wong and Y. Wu and Zhang, \{W. H.\} and D. Absher and G. Asiki and I. Barroso and Been, \{L. F.\} and Bolton, \{J. L.\} and Bonnycastle, \{L. L.\} and P. Brambilla and Burnett, \{M. S.\} and G. Cesana and M. Dimitriou and Doney, \{A. S. F.\} and A. Doring and P. Elliott and Epstein, \{S. E.\} and Eyjolfsson, \{G. I.\} and B. Gigante and Goodarzi, \{M. O.\} and H. Grallert and Gravito, \{M. L.\} and Groves, \{C. J.\} and G. Hallmans and Hartikainen, \{A. L.\} and C. Hayward and D. Hernandez and Hicks, \{A. A.\} and H. Holm and Hung, \{Y. J.\} and T. Illig and Jones, \{M. R.\} and P. Kaleebu and Kastelein, \{J. J. P.\} and Khaw, \{K. T.\} and E. Kim and N. Klopp and P. Komulainen and M. Kumari and C. Langenberg and T. Lehtimaki and Lin, \{S. Y.\} and J. Lindstrom and Loos, \{R. J. F.\} and F. Mach and McArdle, \{W. L.\} and C. Meisinger and Mitchell, \{B. D.\} and G. Muller and R. Nagaraja and N. Narisu and Nieminen, \{T. V. M.\} and Nsubuga, \{R. N.\} and I. Olafsson and Ong, \{K. K.\} and A. Palotie and T. Papamarkou and C. Pomilla and A. Pouta and Rader, \{D. J.\} and Reilly, \{M. P.\} and Ridker, \{P. M.\} and F. Rivadeneira and I. Rudan and A. Ruokonen and N. Samani and H. Scharnagl and J. Seeley and K. Silander and A. Stancakova and K. Stirrups and Swift, \{A. J.\} and L. Tiret and Uitterlinden, \{A. G.\} and \{van Pelt\}, \{L. J.\} and S. Vedantam and N. Wainwright and C. Wijmenga and Wild, \{S. H.\} and G. Willemsen and T. Wilsgaard and Wilson, \{J. F.\} and Young, \{E. H.\} and Zhao, \{J. H.\} and Adair, \{L. S.\} and D. Arveiler and Assimes, \{T. L.\} and S. Bandinelli and F. Bennett and M. Bochud and Boehm, \{B. O.\} and Boomsma, \{D. I.\} and Borecki, \{I. B.\} and Bornstein, \{S. R.\} and P. Bovet and M. Burnier and H. Campbell and A. Chakravarti and Chambers, \{J. C.\} and Chen, \{Y. D. I.\} and Collins, \{F. S.\} and Cooper, \{R. S.\} and J. Danesh and G. Dedoussis and \{de Faire\}, U. and Feranil, \{A. B.\} and J. Ferrieres and L. Ferrucci and Freimer, \{N. B.\} and C. Gieger and Groop, \{L. C.\} and V. Gudnason and U. Gyllensten and A. Hamsten and Harris, \{T. B.\} and A. Hingorani and Hirschhorn, \{J. N.\} and A. Hofman and Hovingh, \{G. K.\} and Hsiung, \{C. A.\} and Humphries, \{S. E.\} and Hunt, \{S. C.\} and K. Hveem and C. Iribarren and Jarvelin, \{M. R.\} and A. Jula and M. Kahonen and J. Kaprio and A. Kesaniemi and M. Kivimaki and Kooner, \{J. S.\} and Koudstaal, \{P. J.\} and Krauss, \{R. M.\} and D. Kuh and J. Kuusisto and Kyvik, \{K. O.\} and M. Laakso and Lakka, \{T. A.\} and L. Lind and Lindgren, \{C. M.\} and Martin, \{N. G.\} and W. Marz and McCarthy, \{M. I.\} and McKenzie, \{C. A.\} and P. Meneton and A. Metspalu and L. Moilanen and Morris, \{A. D.\} and Munroe, \{P. B.\} and I. Njolstad and Pedersen, \{N. L.\} and C. Power and Pramstaller, \{P. P.\} and Price, \{J. F.\} and Psaty, \{B. M.\} and T. Quertermous and R. Rauramaa and D. Saleheen and V. Salomaa and Sanghera, \{D. K.\} and J. Saramies and Schwarz, \{P. E. H.\} and Sheu, \{W. H. H.\} and Shuldiner, \{A. R.\} and A. Siegbahn and Spector, \{T. D.\} and K. Stefansson and Strachan, \{D. P.\} and Tayo, \{B. O.\} and E. Tremoli and J. Tuomilehto and M. Uusitupa and \{van Duijn\}, \{C. M.\} and P. Vollenweider and L. Wallentin and Wareham, \{N. J.\} and Whitfield, \{J. B.\} and Wolffenbuttel, \{B. H. R.\} and Ordovas, \{J. M.\} and E. Boerwinkle and Palmer, \{C. N. A.\} and U. Thorsteinsdottir and Chasman, \{D. I.\} and Rotter, \{J. I.\} and Franks, \{P. W.\} and S. Ripatti and Cupples, \{L. A.\} and Sandhu, \{M. S.\} and Rich, \{S. S.\} and M. Boehnke and P. Deloukas and S. Kathiresan and Mohlke, \{K. L.\} and E. Ingelsson and Abecasis, \{G. R.\} and \{Global Lipids Genetics\}, Consortium",

year = "2013",

doi = "10.1038/ng.2797",

language = "English",

volume = "45",

pages = "1274--1283",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Research",

}

Willer, CJ, Schmidt, EM, Sengupta, S, Peloso, GM, Gustafsson, S, Kanoni, S, Ganna, A, Chen, J, Buchkovich, ML, Mora, S, Beckmann, JS, Bragg-Gresham, JL, Chang, HY, Demirkan, A, Den Hertog, HM, Do, R, Donnelly, LA, Ehret, GB, Esko, T, Feitosa, MF, Ferreira, T, Fischer, K, Fontanillas, P, Fraser, RM, Freitag, DF, Gurdasani, D, Heikkila, K, Hypponen, E, Isaacs, A, Jackson, AU, Johansson, A, Johnson, T, Kaakinen, M, Kettunen, J, Kleber, ME, Li, XH, Luan, JA, Lyytikainen, LP, Magnusson, PKE, Mangino, M, Mihailov, E, Montasser, ME, Muller-Nurasyid, M, Nolte, IM, O'Connell, JR, Palmer, CD, Perola, M, Petersen, AK, Sanna, S, Saxena, R, Service, SK, Shah, S, Shungin, D, Sidore, C, Song, C, Strawbridge, RJ, Surakka, I, Tanaka, T, Teslovich, TM, Thorleifsson, G, Van den Herik, EG, Voight, BF, Volcik, KA, Waite, LL, Wong, A, Wu, Y, Zhang, WH, Absher, D, Asiki, G, Barroso, I, Been, LF, Bolton, JL, Bonnycastle, LL, Brambilla, P, Burnett, MS, Cesana, G, Dimitriou, M, Doney, ASF, Doring, A, Elliott, P, Epstein, SE, Eyjolfsson, GI, Gigante, B, Goodarzi, MO, Grallert, H, Gravito, ML, Groves, CJ, Hallmans, G, Hartikainen, AL, Hayward, C, Hernandez, D, Hicks, AA, Holm, H, Hung, YJ, Illig, T, Jones, MR, Kaleebu, P, Kastelein, JJP, Khaw, KT, Kim, E, Klopp, N, Komulainen, P, Kumari, M, Langenberg, C, Lehtimaki, T, Lin, SY, Lindstrom, J, Loos, RJF, Mach, F, McArdle, WL, Meisinger, C, Mitchell, BD, Muller, G, Nagaraja, R, Narisu, N, Nieminen, TVM, Nsubuga, RN, Olafsson, I, Ong, KK, Palotie, A, Papamarkou, T, Pomilla, C, Pouta, A, Rader, DJ, Reilly, MP, Ridker, PM, Rivadeneira, F, Rudan, I, Ruokonen, A, Samani, N, Scharnagl, H, Seeley, J, Silander, K, Stancakova, A, Stirrups, K, Swift, AJ, Tiret, L, Uitterlinden, AG, van Pelt, LJ, Vedantam, S, Wainwright, N, Wijmenga, C, Wild, SH, Willemsen, G, Wilsgaard, T, Wilson, JF, Young, EH, Zhao, JH, Adair, LS, Arveiler, D, Assimes, TL, Bandinelli, S, Bennett, F, Bochud, M, Boehm, BO, Boomsma, DI, Borecki, IB, Bornstein, SR, Bovet, P, Burnier, M, Campbell, H, Chakravarti, A, Chambers, JC, Chen, YDI, Collins, FS, Cooper, RS, Danesh, J, Dedoussis, G, de Faire, U, Feranil, AB, Ferrieres, J, Ferrucci, L, Freimer, NB, Gieger, C, Groop, LC, Gudnason, V, Gyllensten, U, Hamsten, A, Harris, TB, Hingorani, A, Hirschhorn, JN, Hofman, A, Hovingh, GK, Hsiung, CA, Humphries, SE, Hunt, SC, Hveem, K, Iribarren, C, Jarvelin, MR, Jula, A, Kahonen, M, Kaprio, J, Kesaniemi, A, Kivimaki, M, Kooner, JS, Koudstaal, PJ, Krauss, RM, Kuh, D, Kuusisto, J, Kyvik, KO, Laakso, M, Lakka, TA, Lind, L, Lindgren, CM, Martin, NG, Marz, W, McCarthy, MI, McKenzie, CA, Meneton, P, Metspalu, A, Moilanen, L, Morris, AD, Munroe, PB, Njolstad, I, Pedersen, NL, Power, C, Pramstaller, PP, Price, JF, Psaty, BM, Quertermous, T, Rauramaa, R, Saleheen, D, Salomaa, V, Sanghera, DK, Saramies, J, Schwarz, PEH, Sheu, WHH, Shuldiner, AR, Siegbahn, A, Spector, TD, Stefansson, K, Strachan, DP, Tayo, BO, Tremoli, E, Tuomilehto, J, Uusitupa, M, van Duijn, CM, Vollenweider, P, Wallentin, L, Wareham, NJ, Whitfield, JB, Wolffenbuttel, BHR, Ordovas, JM, Boerwinkle, E, Palmer, CNA, Thorsteinsdottir, U, Chasman, DI, Rotter, JI, Franks, PW, Ripatti, S, Cupples, LA, Sandhu, MS, Rich, SS, Boehnke, M, Deloukas, P, Kathiresan, S, Mohlke, KL, Ingelsson, E, Abecasis, GR & Global Lipids Genetics, C 2013, 'Discovery and refinement of loci associated with lipid levels', Nature Genetics, bind 45, s. 1274-1283. https://doi.org/10.1038/ng.2797

TY - JOUR

T1 - Discovery and refinement of loci associated with lipid levels

AU - Willer, C. J.

AU - Schmidt, E. M.

AU - Sengupta, S.

AU - Peloso, G. M.

AU - Gustafsson, S.

AU - Kanoni, S.

AU - Ganna, A.

AU - Chen, J.

AU - Buchkovich, M. L.

AU - Mora, S.

AU - Beckmann, J. S.

AU - Bragg-Gresham, J. L.

AU - Chang, H. Y.

AU - Demirkan, A.

AU - Den Hertog, H. M.

AU - Do, R.

AU - Donnelly, L. A.

AU - Ehret, G. B.

AU - Esko, T.

AU - Feitosa, M. F.

AU - Ferreira, T.

AU - Fischer, K.

AU - Fontanillas, P.

AU - Fraser, R. M.

AU - Freitag, D. F.

AU - Gurdasani, D.

AU - Heikkila, K.

AU - Hypponen, E.

AU - Isaacs, A.

AU - Jackson, A. U.

AU - Johansson, A.

AU - Johnson, T.

AU - Kaakinen, M.

AU - Kettunen, J.

AU - Kleber, M. E.

AU - Li, X. H.

AU - Luan, J. A.

AU - Lyytikainen, L. P.

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AU - Global Lipids Genetics, Consortium

PY - 2013

Y1 - 2013

N2 - Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P

AB - Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P

KW - CORONARY-ARTERY-DISEASE DENSITY-LIPOPROTEIN CHOLESTEROL GENOME-WIDE ASSOCIATION HEART-DISEASE CARDIOVASCULAR-DISEASE SUSCEPTIBILITY LOCI IDENTIFIES 13 RISK GENE METAANALYSIS

KW - Cholesterol

KW - LDL/blood

KW - European Continental Ancestry Group/genetics

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Humans

KW - African Continental Ancestry Group/genetics

KW - Genotype

KW - Asian Continental Ancestry Group/genetics

KW - HDL/blood

KW - Triglycerides/blood

KW - Lipids/blood

KW - Coronary Artery Disease/blood

U2 - 10.1038/ng.2797

DO - 10.1038/ng.2797

M3 - Article

SN - 1061-4036

VL - 45

SP - 1274

EP - 1283

JO - Nature Genetics

JF - Nature Genetics

ER -