Discordance between the Cortisol Response to Insulin‐Hypoglycemia and 30‐Minute ACTH Stimulation Test in Chronic Alcoholic Men

G. Moos Knudsen, H. Christensen, D. Berild, B. Melgaard, C. Kirkegaard, H. Hasselbalch

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    Abstrakt

    An insulin hypoglycemia test and a 30‐min ACTH stimulation test was performed in 10 chronic alcoholic men, who had been abstinent from alcohol for at least one month. Attenuated serum cortisol responses were found in six of the patients despite a normal ACTH test. Four patients showed normal responses to both the insulin hypoglycemia test and the short ACTH test. No correlation was demonstrated between the cortisol response and the severity of alcoholism, cerebral atrophy, and peripheral neuropathy. It is concluded that in chronic alcoholism the short ACTH test may fail in disclosing hypofunction of the integrated hypothalamic‐pituitaryad‐renocortical (HPA) axis as assessed with the insulin hypoglycemia test.

    OriginalsprogEngelsk
    Sider (fra-til)323-325
    Antal sider3
    TidsskriftAlcoholism: Clinical and Experimental Research
    Vol/bind11
    Udgave nummer4
    DOI
    StatusUdgivet - aug. 1987

    Fingeraftryk Udforsk hvilke forskningsemner 'Discordance between the Cortisol Response to Insulin‐Hypoglycemia and 30‐Minute ACTH Stimulation Test in Chronic Alcoholic Men' indeholder.

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