TY - JOUR
T1 - Differential diagnosis of jaundice
T2 - a pocket diagnostic chart
AU - The Copenhagen Computer Icterus Group
AU - Matzen, Peter
AU - Malchow‐Møller, Axel
AU - Hilden, Jørgen
AU - Thomsen, Carsten
AU - Svendsen, Lars Bo
AU - Gammelgaard, Jens
AU - Juhl, Erik
PY - 1984/12
Y1 - 1984/12
N2 - ABSTRACT— Based on extensive clinical and clinical chemical information (107 different items) from 1002 jaundiced patients, we developed a diagnostic algorithm which was evaluated on a test sample of another 110 jaundiced patients. A primary classification into categories of obstructive jaundice (probability of obstruction ≥0.80), non‐obstructive jaundice (probability of obstruction ≤0.20), and of doubtful causes of jaundice (probability of obstruction: 0.20–0.80) was attempted. Among 234 patients in the data base who were classified as obstructive, 220 (94%) proved to be so, as did 36 (97%) of 37 in the test sample. The corresponding figures for non‐obstructive jaundice were 463 (96%) of 483 patients correctly classified in the data base and 47 (92%) of 51 patients in the test sample. Altogether 69% of the patients in the data base and 75% of those in the test sample were correctly classified, in 27% and 20% the cause of jaundice was doubtful, and only 4% and 5%, respectively, were misclassified. A slight majority of the patients in whom the algorithmic diagnoses were doubtful proved obstructive. A close correlation was found between the preliminary diagnoses made by the algorithm and by the clinicians. A secondary classification of the patients by the algorithm into benign versus malignant causes of obstructive jaundice performed equally well in the data base and the test sample.
AB - ABSTRACT— Based on extensive clinical and clinical chemical information (107 different items) from 1002 jaundiced patients, we developed a diagnostic algorithm which was evaluated on a test sample of another 110 jaundiced patients. A primary classification into categories of obstructive jaundice (probability of obstruction ≥0.80), non‐obstructive jaundice (probability of obstruction ≤0.20), and of doubtful causes of jaundice (probability of obstruction: 0.20–0.80) was attempted. Among 234 patients in the data base who were classified as obstructive, 220 (94%) proved to be so, as did 36 (97%) of 37 in the test sample. The corresponding figures for non‐obstructive jaundice were 463 (96%) of 483 patients correctly classified in the data base and 47 (92%) of 51 patients in the test sample. Altogether 69% of the patients in the data base and 75% of those in the test sample were correctly classified, in 27% and 20% the cause of jaundice was doubtful, and only 4% and 5%, respectively, were misclassified. A slight majority of the patients in whom the algorithmic diagnoses were doubtful proved obstructive. A close correlation was found between the preliminary diagnoses made by the algorithm and by the clinicians. A secondary classification of the patients by the algorithm into benign versus malignant causes of obstructive jaundice performed equally well in the data base and the test sample.
KW - bile duct obstruction
KW - cholestasis
KW - diagnostic tests
KW - differential diagnosis
KW - extrahepatic
KW - jaundice
UR - http://www.scopus.com/inward/record.url?scp=0021720766&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0676.1984.tb00952.x
DO - 10.1111/j.1600-0676.1984.tb00952.x
M3 - Article
C2 - 6521616
AN - SCOPUS:0021720766
SN - 0106-9543
VL - 4
SP - 360
EP - 371
JO - Liver
JF - Liver
IS - 6
ER -