Die Montreal-definition und -klassifikation der gastroösophagealen refluxkrankheit: Ein globales evidenzbasiertes konsensus-papier

S. V. Van Zanten, P. Kahrilas, J. Dent, R. Jones, Nimish Vakil*, Lars Agreus, David Armstrong, Stephen Attwood, Jean Francois Bergman, Marc André Bigard, Patricia Blount, Peter Bytzer, Tsutomu Chiba, Gianfranco Delle Fave, Hashem El-Serag, Damming Fan, Ronnie Fass, Nigel Flook, Jean Paul Galmiche, Michio HongoFrancisco Huera Iga, Janusz Jankowski, David Johnson, Folke Johnssorn, Peter Katelaris, Yoshi Kinoshita, Elly Klinkenberg-Knol, Joachim Labenz, Harley Liker, Peter Malfertheiner, Hiroto Miwa, Paul Moayyedi, Fabio Pace, Joachim Prado, Joel Richter, Graciela Salis, Lin San-Ren, Prateek Sharma, Vincenco Stanghellini, Jan Tack, Nicholas Talley, Benjamin Wong, Yuan Yaozong, Carlos Zapata

*Corresponding author af dette arbejde

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review


    Aim: A world-wide recognised and accepted definition and classification of gastroesophageal reflux disease (GERD) would be highly desirable for research and clinical practice. The purpose of this project was to develop such a generally accepted definition and classification that could be used equally by patients, physicians, and supervisory bodies. Methods: In order to ensure a consensus among the participating experts a modifieddelphi process with a step-wise selection modality was employed. For this the working group of five persons formulated a series of statements on the basis of a systematic search of the literature using three databases (Embase, Cochrane-Study register, Medline). Then these statements were developed further for two years, revised and finally passed as consensus. The consensus group consisted of 44 experts from 18 countries. Each key vote was held on the basis of a six-point scale. A "consensus" was considered to have been reached when two-thirds of the participants voted in favour of the respective statement. Results: The level of agreement between the experts increased in the course of the multistep decision process, in the individual voting steps requiring at least two-thirds of the participants, the results were at first 86%, then 88% through to 94% and finally 100% in favour of the chosen statement. In the final voting, 94% of the final 51 statements were accepted by 90% of the consensus group. 90% of all statements were accepted unanimously or with only minor reservations. GERD was defined as a disease that is associated with troublesome symptoms and/or complications on account of reflux of stomach contents into the esophagus. The complaints are divided into esophageal and extra-esophageal syndromes. Among the novel aspects of this definition are the patient-orientated approach that is independent of endoscopic findings, the classification of the ailment into independent syndromes as well as the consideration of laryngitis, cough, asthma and dental problems as possible GERD syndromes. Furthermore, a new definition of suspected or demonstrated Barrett's esophagus is proposed. Conclusion: Irrespective of country-specific differences in terminology, language, prevalence and manifestations of this disease, evidence-based, world-wide valid consensus definitions are possible. A global consensus definition of GERD will simplify disease management, make mutual research possible and help in the design of generally valid studies. This will not only help the patient but also the physician and supervisory bodies.

    Bidragets oversatte titelThe Montreal definition and classification of gastroesophageal reflux disease: A global, evidence-based consensus paper
    Sider (fra-til)1125-1140
    Antal sider16
    TidsskriftZeitschrift fur Gastroenterologie
    Udgave nummer11
    StatusUdgivet - 1 nov. 2007


    • Barrett's disease
    • Evidence-based medicine
    • Gastroesophageal reflux disease
    • GERD
    • Montreal classification


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