Diagnosis of abominal metastases in small cell carcinoma of the lung: a prospective study of computer tomography and ultrasonography

Lise Ingemann Jensen*, Fred R. Hirsch, Kurt Peters, Flemming Jensen, Carsten Thomsen

*Corresponding author af dette arbejde

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review

    Abstract

    The incidence of abdominal metastases from small cell carcinoma of the lung (SCLC) was evaluated in a comparative, prospective study by means of computed tomography (CT) and ultrasonography (US) with biopsy. In 77 patients CT and US were performed and 60 underwent peritoneoscopy (PSC) as well. Altogether, 30% had liver metastases at CT and 25% at US. For liver metastases the diagnostic sensitivity, specificity and negative, predictive value were without statistical difference. The predictive positive value was slightly lower for CT than for US (0.67 vs. 0.86). Positive liver biopsies obtained with US or PSC proved the presence of metastases. Extrahepatic, abdominal metastases were diagnosed in 16 patients (21%), 15 of whom had lesions at CT and 6 at US. Only one patient had extrahepatic metastases seen with US but not at CT. Of these patients, 4 had metastases to the liver. Thus, in 11 patients the extrahepatic metastases were diagnosed exclusively by CT (14%), whereas US diagnosed these in 3 patients (4%) (P<0.05). Most lesions were located to the retroperitoneal space and the metastases to the adrenals. CT is recommended as the first-choice examination in staging patients with SCLC, preferably followed by biopsy.

    OriginalsprogEngelsk
    Sider (fra-til)37-45
    Antal sider9
    TidsskriftLung Cancer
    Vol/bind8
    Udgave nummer1
    DOI
    StatusUdgivet - apr. 1992

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