TY - JOUR
T1 - Diabetes and elevated plasma glucose in heart valve calcification and disease
T2 - the Copenhagen General Population Study
AU - Kaltoft, Morten
AU - Afzal, Shoaib
AU - Nordestgaard, Børge G
AU - Sigvardsen, Per E
AU - Kühl, Jørgen Tobias
AU - Fuchs, Andreas
AU - Køber, Lars
AU - Kofoed, Klaus F
AU - Langsted, Anne
N1 - © The Author(s) 2025. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For commercial re-use, please contact [email protected] for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact [email protected].
PY - 2025/2/26
Y1 - 2025/2/26
N2 - AIM: The only treatment available for aortic valve stenosis is valve replacement, which makes it important to identify modifiable risk factors. We tested the hypotheses that diabetes and elevated plasma glucose are associated with aortic and mitral valve calcification and aortic valve stenosis, and that these associations are explained partly by elevated plasma triglycerides, hypertension, and body mass index.METHODS: In the Copenhagen General Population Study with 110,291 individuals, we evaluated risk of aortic valve stenosis and mitral valve regurgitation from health registers, and in a subset of 12,006 cardiac CT scanned individuals aortic and mitral valve calcification.RESULTS: Of individuals with cardiac CT, 3018(25%) had aortic and 1521(13%) had mitral valve calcification. For individuals with versus without diabetes, the multivariable adjusted odds ratios were 1.67(95%:1.34-2.08) for aortic and 1.89(1.48-2.40) for mitral valve calcification. The corresponding hazard ratio was 1.71(1.44-2.03) for aortic valve stenosis.For individuals with glucose ≥6.6mmol/L(≥118mg/dL) versus ≤5.1mmol/L(≤92 mg/dL), the multivariable adjusted odds ratios were 1.27(1.07-1.52) for aortic and 1.44(1.18-1.77) for mitral valve calcification. The corresponding hazard ratio was 1.33(1.12-1.57) for aortic valve stenosis.In the relationship between diabetes and aortic valve stenosis, 4.8%(95%CI:0.5-11%) of the association was explained by plasma triglycerides, 19%(14-28%) by hypertension, and 27%(18-43%) by body mass index.CONCLUSIONS: Diabetes and elevated plasma glucose were associated with risk of aortic and mitral valve calcification and aortic valve stenosis. The risk of aortic valve stenosis was partly explained by elevated plasma triglycerides, hypertension, and body mass index.
AB - AIM: The only treatment available for aortic valve stenosis is valve replacement, which makes it important to identify modifiable risk factors. We tested the hypotheses that diabetes and elevated plasma glucose are associated with aortic and mitral valve calcification and aortic valve stenosis, and that these associations are explained partly by elevated plasma triglycerides, hypertension, and body mass index.METHODS: In the Copenhagen General Population Study with 110,291 individuals, we evaluated risk of aortic valve stenosis and mitral valve regurgitation from health registers, and in a subset of 12,006 cardiac CT scanned individuals aortic and mitral valve calcification.RESULTS: Of individuals with cardiac CT, 3018(25%) had aortic and 1521(13%) had mitral valve calcification. For individuals with versus without diabetes, the multivariable adjusted odds ratios were 1.67(95%:1.34-2.08) for aortic and 1.89(1.48-2.40) for mitral valve calcification. The corresponding hazard ratio was 1.71(1.44-2.03) for aortic valve stenosis.For individuals with glucose ≥6.6mmol/L(≥118mg/dL) versus ≤5.1mmol/L(≤92 mg/dL), the multivariable adjusted odds ratios were 1.27(1.07-1.52) for aortic and 1.44(1.18-1.77) for mitral valve calcification. The corresponding hazard ratio was 1.33(1.12-1.57) for aortic valve stenosis.In the relationship between diabetes and aortic valve stenosis, 4.8%(95%CI:0.5-11%) of the association was explained by plasma triglycerides, 19%(14-28%) by hypertension, and 27%(18-43%) by body mass index.CONCLUSIONS: Diabetes and elevated plasma glucose were associated with risk of aortic and mitral valve calcification and aortic valve stenosis. The risk of aortic valve stenosis was partly explained by elevated plasma triglycerides, hypertension, and body mass index.
U2 - 10.1093/eurjpc/zwaf106
DO - 10.1093/eurjpc/zwaf106
M3 - Article
C2 - 40036235
SN - 2047-4873
JO - European Journal of Preventive Cardiology
JF - European Journal of Preventive Cardiology
ER -