DESMOPRESSIN I BEHANDLING AF HAEMORAGISK DIATESE

D. Haar*, H. C. Hasselbalch

*Corresponding author af dette arbejde

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

    Abstrakt

    Over the past several years, the use of 1-deamino-8D-arginine vasopressin (DDAVP), a synthetic analogue of vasopressin, has been found to be useful in the treatment of patients with abnormal bleeding tendency. This article is a review of inherited and acquired disorders with prolonged bleeding time in which DDAVP is supposed to shorten the bleeding time. DDAVP is established as effective therapy of the abnormal haemostasis in mild or moderate haemophilia A and von Willebrand's disease. Frequently, DDAVP infusions are used to control bleeding in patients with uraemia. Bleeding time is also significantly shortened in patients with liver cirrhosis, although randomized trials of DDAVP therapy of gastrointestinal bleeding in this group of patients are still needed. Shortening or normalization of the bleeding time with DDAVP has also been observed in patients with inherited platelet dysfunctions, acquired disorders of haemostasis and abnormal haemostasis in chronic myeloproliferative diseases. In addition, preoperative treatment with DDAVP seems to reduce blood loss during surgery.

    Bidragets oversatte titelDesmopressin in treatment of haemorrhagic diathesis
    OriginalsprogDansk
    Sider (fra-til)6713-6715
    Antal sider3
    TidsskriftUgeskrift for laeger
    Vol/bind157
    Udgave nummer48
    StatusUdgivet - 1 jan. 1995

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