Depth of neutrophil nadir after first cycle of R-CHOP predicts outcome in diffuse large B-cell lymphoma - a nationwide population-based cohort study

Michael Roost Clausen, Sinna Pilgaard Ulrichsen, Thomas Stauffer Larsen, Christian B Poulsen, Selma Tojaga, Per Trøllund Pedersen, Jakob Madsen, Robert Schou Pedersen, Pär Lars Josefsson, Jette Sønderskov Gørløv, Mette Nørgaard, Francesco d'Amore

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Abstrakt

We investigated if survival was predicted by nadir neutrophil counts after the first cycle of R-CHOP in patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL). Neutrophil counts (109/L) were categorized in four grades in the nadir time frame. Prognostic indices and comorbidity levels were calculated and used to adjust the Cox regression model. Kaplan-Meier and Cox regression methods were used to estimate and compare survival. We identified 965 patients. Grade 4 neutropenia was present in 432 (45%). Grade 0 patients had a 5-year overall survival of 67%, grade 1-2: 78%, grade 3: 64%, and grade 4: 57%. Compared with grade 0 adjusted hazard ratios (HR) for death were: 0.77 (95% CI 0.49-1.21) for grade 1-2, 1.18 (95% CI 0.82-1.71) for grade 3, and 1.33 (95% CI 1.02-1.73) for grade 4. Grade 4 neutropenia after the 1st cycle of chemotherapy predicted inferior outcome compared with grade 0 and 1-2. Grade 1-2 neutropenia seemed to have superior outcome.

OriginalsprogEngelsk
Sider (fra-til)1950-1957
Antal sider8
TidsskriftLeukemia and Lymphoma
Vol/bind60
Udgave nummer8
DOI
StatusUdgivet - aug. 2019

Fingeraftryk Udforsk hvilke forskningsemner 'Depth of neutrophil nadir after first cycle of R-CHOP predicts outcome in diffuse large B-cell lymphoma - a nationwide population-based cohort study' indeholder.

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