TY - JOUR
T1 - Depression and cancer risk
T2 - A register-based study of patients hospitalized with affective disorders, Denmark, 1969-1993
AU - Dalton, Susanne Oksbjerg
AU - Mellemkjær, Lene
AU - Olsen, Jørgen H.
AU - Mortensen, Preben B.
AU - Johansen, Christoffer
PY - 2002/6/15
Y1 - 2002/6/15
N2 - The authors investigated the cancer risk of patients hospitalized for depression in a nationwide Danish cohort study. All 89,491 adults in Denmark who had been admitted to a hospital with depression, as defined in the International Classification of Diseases, Eighth Revision, between 1969 and 1993 were identified. There were 1,117,006 person-years of follow-up. Incidence rates of all cancers and of site-specific cancers were compared with national incidence rates for first primary cancers, with data being adjusted for sex, age, and calendar time. A total of 9,922 cases of cancer were diagnosed in the cohort, with 9,434.6 having been expected; this yielded a standardized incidence ratio of 1.05 (95% confidence interval (Cl): 1.03, 1.07). The risk of cancer was increased for the first year after hospital admission, with brain cancer especially occurring more frequently than expected. When the first year of follow-up was excluded, the increase was attributable mainly to an increased risk of tobacco-related cancers: Standardized incidence ratios for non-tobacco-related cancers were 1.00 (95% Cl: 0.97, 1.03) after 1-9 years of follow-up and 0.99 (95% Cl: 0.95, 1.02) after 10 or more years of follow-up. These data provide no support for the hypothesis that depression independently increases risk of cancer, but they emphasize the deleterious effect that depression can have on lifestyle factors.
AB - The authors investigated the cancer risk of patients hospitalized for depression in a nationwide Danish cohort study. All 89,491 adults in Denmark who had been admitted to a hospital with depression, as defined in the International Classification of Diseases, Eighth Revision, between 1969 and 1993 were identified. There were 1,117,006 person-years of follow-up. Incidence rates of all cancers and of site-specific cancers were compared with national incidence rates for first primary cancers, with data being adjusted for sex, age, and calendar time. A total of 9,922 cases of cancer were diagnosed in the cohort, with 9,434.6 having been expected; this yielded a standardized incidence ratio of 1.05 (95% confidence interval (Cl): 1.03, 1.07). The risk of cancer was increased for the first year after hospital admission, with brain cancer especially occurring more frequently than expected. When the first year of follow-up was excluded, the increase was attributable mainly to an increased risk of tobacco-related cancers: Standardized incidence ratios for non-tobacco-related cancers were 1.00 (95% Cl: 0.97, 1.03) after 1-9 years of follow-up and 0.99 (95% Cl: 0.95, 1.02) after 10 or more years of follow-up. These data provide no support for the hypothesis that depression independently increases risk of cancer, but they emphasize the deleterious effect that depression can have on lifestyle factors.
KW - Cohort studies
KW - Depression
KW - Neoplasms
KW - Registries
UR - http://www.scopus.com/inward/record.url?scp=0037097842&partnerID=8YFLogxK
U2 - 10.1093/aje/155.12.1088
DO - 10.1093/aje/155.12.1088
M3 - Article
C2 - 12048222
AN - SCOPUS:0037097842
VL - 155
SP - 1088
EP - 1095
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
SN - 0002-9262
IS - 12
ER -