Demonstration of pepsinogen C in human pancreatic islets

P. B. Szecsi*, H. Halgreen, S. S. Poulsen, C. K. Axelsson, M. Damkjær-Nielsen, T. Kjær, B. Foltmann

*Corresponding author af dette arbejde

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review

    Abstract

    Pancreatic tissue from 16 post mortem kidney donors have been examined for the content of pepsinogens. A zymogen with electrophoretic mobility, isoelectric point and molecular weight equal to that of pepsinogen C of gastric origin was found in all specimens. A comparison between pepsinogen C extracted from pancreatic tissue and gastric mucosa demonstrated immunological identity. Quantitative measurements with a radioimmunoassay showed pepsinogen C concentrations in pancreatic tissue three to 80 times higher than those of blood serum. Immunohistochemical staining gave positive reaction for pepsinogen C only in the alpha cells of the pancreatic islets.

    OriginalsprogEngelsk
    Sider (fra-til)1208-1214
    Antal sider7
    TidsskriftGut
    Vol/bind28
    Udgave nummer10
    DOI
    StatusUdgivet - 1 jan. 1987

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