Delayed early proprioceptive information processing in schizophrenia

Sidse M. Arnfred*, Ralf P. Hemmingsen, Josef Parnas

*Corresponding author af dette arbejde

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    Abstrakt

    It was first suggested that disordered proprioception was a core feature of schizophrenia by Sandor Rado in 1953. Using a recently designed proprioceptive event-related potential paradigm based on a change of load, we studied 12 unmedicated male out-patients with schizophrenia and 24 controls. In the patients, the early contralateral parietal activity was delayed and later central activity had increased amplitude, but gating was unaffected. The results could be understood within the 'deficiency of corollary discharge' model of schizophrenia but not within the 'filtering' theory. Further studies, including psychiatric controls, are necessary to verify the specificity of the abnormality.

    OriginalsprogEngelsk
    Sider (fra-til)558-559
    Antal sider2
    TidsskriftBritish Journal of Psychiatry
    Vol/bind189
    Udgave nummerDEC.
    DOI
    StatusUdgivet - 1 dec. 2006

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