TY - JOUR
T1 - Danish Whole-Genome-Sequenced Candida albicans and Candida glabrata Samples Fit into Globally Prevalent Clades
AU - Szarvas, Judit
AU - Rebelo, Ana Rita
AU - Bortolaia, Valeria
AU - Leekitcharoenphon, Pimlapas
AU - Schrøder Hansen, Dennis
AU - Nielsen, Hans Linde
AU - Nørskov-Lauritsen, Niels
AU - Kemp, Michael
AU - Røder, Bent Løwe
AU - Frimodt-Møller, Niels
AU - Søndergaard, Turid Snekloth
AU - Coia, John Eugenio
AU - Østergaard, Claus
AU - Westh, Henrik
AU - Aarestrup, Frank Møller
PY - 2021/11/12
Y1 - 2021/11/12
N2 - Candida albicans and Candida glabrata are opportunistic fungal pathogens with increasing incidence worldwide and higher-than-expected prevalence in Denmark. We whole-genome sequenced yeast isolates collected from Danish Clinical Microbiology Laboratories to obtain an overview of the Candida population in the country. The majority of the 30 C. albicans isolates were found to belong to three globally prevalent clades, and, with one exception, the remaining isolates were also predicted to cluster with samples from other geographical locations. Similarly, most of the eight C. glabrata isolates were predicted to be prevalent subtypes. Antifungal susceptibility testing proved all C. albicans isolates to be susceptible to both azoles and echinocandins. Two C. glabrata isolates presented azole-resistant phenotypes, yet all were susceptible to echinocandins. There is no indication of causality between population structure and resistance phenotypes for either species.
AB - Candida albicans and Candida glabrata are opportunistic fungal pathogens with increasing incidence worldwide and higher-than-expected prevalence in Denmark. We whole-genome sequenced yeast isolates collected from Danish Clinical Microbiology Laboratories to obtain an overview of the Candida population in the country. The majority of the 30 C. albicans isolates were found to belong to three globally prevalent clades, and, with one exception, the remaining isolates were also predicted to cluster with samples from other geographical locations. Similarly, most of the eight C. glabrata isolates were predicted to be prevalent subtypes. Antifungal susceptibility testing proved all C. albicans isolates to be susceptible to both azoles and echinocandins. Two C. glabrata isolates presented azole-resistant phenotypes, yet all were susceptible to echinocandins. There is no indication of causality between population structure and resistance phenotypes for either species.
U2 - 10.3390/jof7110962
DO - 10.3390/jof7110962
M3 - Article
C2 - 34829249
SN - 2309-608X
VL - 7
JO - Journal of Fungi
JF - Journal of Fungi
IS - 11
ER -