Cytotoxic CD8+ T cells in cancer and cancer immunotherapy

Hans Raskov, Adile Orhan, Jan Pravsgaard Christensen, Ismail Gögenur

Publikation: Bidrag til tidsskriftReviewForskningpeer review

Abstrakt

The functions of, and interactions between, the innate and adaptive immune systems are vital for anticancer immunity. Cytotoxic T cells expressing cell-surface CD8 are the most powerful effectors in the anticancer immune response and form the backbone of current successful cancer immunotherapies. Immune-checkpoint inhibitors are designed to target immune-inhibitory receptors that function to regulate the immune response, whereas adoptive cell-transfer therapies use CD8+ T cells with genetically modified receptors-chimaeric antigen receptors-to specify and enhance CD8+ T-cell functionality. New generations of cytotoxic T cells with genetically modified or synthetic receptors are being developed and evaluated in clinical trials. Furthermore, combinatory regimens might optimise treatment effects and reduce adverse events. This review summarises advances in research on the most prominent immune effectors in cancer and cancer immunotherapy, cytotoxic T cells, and discusses possible implications for future cancer treatment.

OriginalsprogEngelsk
Sider (fra-til)359-367
Antal sider9
TidsskriftBritish Journal of Cancer
Vol/bind124
Udgave nummer2
Tidlig onlinedato15 sep. 2020
DOI
StatusUdgivet - jan. 2021

Fingeraftryk Udforsk hvilke forskningsemner 'Cytotoxic CD8+ T cells in cancer and cancer immunotherapy' indeholder.

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