Cytokine Autoantibodies Are Associated with Infection Risk and Self-Perceived Health: Results from the Danish Blood Donor Study

Jakob H von Stemann, Ole B Pedersen, Henrik Hjalgrim, Christian Erikstrup, Henrik Ullum, Lise W Thørner, Margit Ah Larsen, Kristoffer S Burgdorf, Erik Sørensen, Morten B Hansen, Sisse R Ostrowski

Publikation: Bidrag til tidsskriftArtikelForskningpeer review

Abstrakt

The presence of naturally occurring cytokine-specific autoantibodies (c-aAb) in humans is well established, as well as associations to selected pathologies. However, the overall influence of c-aAb on immunocompetence remains largely unknown. In this paper, we performed a large-scale investigation of c-aAb association with infection risk. A cohort of healthy Danish blood donors was screened for c-aAb against IL-1α, IL-6, IL-10, IFNα, and GM-CSF using a Luminex-based multiplex assay, and results were linked to data from the Danish National Prescription Registry. The filing of an antimicrobial prescription following c-aAb measurement was used as a proxy for impaired immunocompetence. We found that c-aAb against pro-inflammatory cytokines IFNα and GM-CSF tended to associate with increased risk of prescription filings in women, whereas antibodies against anti-inflammatory IL-10 were associated with a lower predicted risk of antimicrobial prescriptions, as well as higher self-perceived health scores. We also observed an association of cumulative c-aAb presence with prescription risk. Our data show that cytokine autoantibodies in healthy individuals associate with various proxies for immunomodulation, with the exact association dependent on the pattern of pro- or anti-inflammatory cytokines targeted. This suggests that c-aAb may express cytokine-modulatory properties in healthy individuals and may be critical to further investigate as biomarkers of immunodeficiency.

OriginalsprogEngelsk
Sider (fra-til)367-377
Antal sider11
TidsskriftJournal of Clinical Immunology
Vol/bind40
Udgave nummer2
Tidlig onlinedato15 jan. 2020
DOI
StatusUdgivet - feb. 2020

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