Convergent Validity of Suffering and Quality of Life as measured by The Hidradenitis Suppurativa Quality of Life

C Kursawe Larsen, R Kjaersgaard Andersen, J Kirby, J Tan, D M Saunte, Gbe Jemec

Publikation: Bidrag til tidsskriftArtikelForskningpeer review


BACKGROUND: Hidradenitis suppurativa (HS) is a painful chronic, recurrent inflammatory skin disease with great impact on Health-Related Quality of Life (HRQOL). Recently Hidradenitis SuppuraTiva cORe outcomes set International Collaboration (HISTORIC) established HRQOL as a core domain set for HS clinical trials, and developed the Hidradenitis Suppurativa Quality of Life (HiSQOL) as a validated outcome measurement instrument.

OBJECTIVES: To provide further convergent validity of HiSQOL by comparing it to Dermatology Life Quality Index (DLQI) and Pictorial Representation of Illness and Self Measure-Revised 2 (PRISM-R2).

METHODS: In this cross-sectional study 103 participants completed HiSQOL, PRISM-R2, and DLQI. PRISM-R2 is an instrument designed to measure suffering and reports the two measures, Illness Perception Measure (IPM) and Self Illness Separation (SIS). Correlation analyses were performed including a sub-analysis for a subgroup of patients with high scores in the HS-specific domains of HiSQOL.

RESULTS: A Very strong correlation was found between HiSQOL and DLQI (ρ = 0.93, p < 2.2∙10-16 , (95% CI: 0.89;0.95)), and moderately strong correlations were found between HiSQOL and SIS (ρ = -0.73, p < 2.2∙10-16 , (95% CI: -0.81;-0.62)) and DLQI and SIS (ρ = -0.70, p < 2.2∙10-16 , (95% CI: -0.79;-0.59)). IPM was positively associated with HiSQOL and DLQI and negatively with SIS.

CONCLUSIONS: HiSQOL is a valid measure of Quality of Life for HS-patients and we suggest that HiSQOL can be used as a measure of suffering as well.

TidsskriftJournal of the European Academy of Dermatology and Venereology : JEADV
StatusE-publikation før trykning - 4 feb. 2021

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