TY - JOUR
T1 - Controlled double-blind trial of the clinical effect of nifedipine in the treatment of idiopathic Raynaud's phenomenon
AU - Gjørup, Thomas
AU - Kelbæk, Henning
AU - Hartling, Ole J.
AU - Nielsen, Steen Levin
PY - 1986/4
Y1 - 1986/4
N2 - Twenty-six patients with idiopathic Raynaud's phenomenon participated in a double-blind, crossover clinical trial comparing the clinical effect of nifedipine with that of placebo. Four patients discontinued the study because of side effects and one patient defaulted at the return visit. Nifedipine significantly reduced frequency and severity of attacks (p < 0.01). In an overall evaluation of drug effectiveness, 19 of 21 patients preferred nifedipine to placebo (p < 0.01). Nifedipine proved to be effective in the treatment of idiopathic Raynaud's phenomenon, but side effects should be expected in some 30%.
AB - Twenty-six patients with idiopathic Raynaud's phenomenon participated in a double-blind, crossover clinical trial comparing the clinical effect of nifedipine with that of placebo. Four patients discontinued the study because of side effects and one patient defaulted at the return visit. Nifedipine significantly reduced frequency and severity of attacks (p < 0.01). In an overall evaluation of drug effectiveness, 19 of 21 patients preferred nifedipine to placebo (p < 0.01). Nifedipine proved to be effective in the treatment of idiopathic Raynaud's phenomenon, but side effects should be expected in some 30%.
UR - http://www.scopus.com/inward/record.url?scp=0022624313&partnerID=8YFLogxK
U2 - 10.1016/0002-8703(86)90109-2
DO - 10.1016/0002-8703(86)90109-2
M3 - Article
C2 - 3513504
AN - SCOPUS:0022624313
SN - 0002-8703
VL - 111
SP - 742
EP - 745
JO - American heart journal
JF - American heart journal
IS - 4
ER -