Controlled double-blind trial of the clinical effect of nifedipine in the treatment of idiopathic Raynaud's phenomenon

Thomas Gjørup, Henning Kelbæk, Ole J. Hartling, Steen Levin Nielsen

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review

    Abstrakt

    Twenty-six patients with idiopathic Raynaud's phenomenon participated in a double-blind, crossover clinical trial comparing the clinical effect of nifedipine with that of placebo. Four patients discontinued the study because of side effects and one patient defaulted at the return visit. Nifedipine significantly reduced frequency and severity of attacks (p < 0.01). In an overall evaluation of drug effectiveness, 19 of 21 patients preferred nifedipine to placebo (p < 0.01). Nifedipine proved to be effective in the treatment of idiopathic Raynaud's phenomenon, but side effects should be expected in some 30%.

    OriginalsprogEngelsk
    Sider (fra-til)742-745
    Antal sider4
    TidsskriftAmerican heart journal
    Vol/bind111
    Udgave nummer4
    DOI
    StatusUdgivet - apr. 1986

    Fingeraftryk Udforsk hvilke forskningsemner 'Controlled double-blind trial of the clinical effect of nifedipine in the treatment of idiopathic Raynaud's phenomenon' indeholder.

    Citationsformater