Complement Profiles in Patients with Amyotrophic Lateral Sclerosis: A Prospective Observational Cohort Study

Anne-Lene Kjældgaard, Katrine Pilely, Karsten Skovgaard Olsen, Anne Øberg Lauritsen, Stephen Wørlich Pedersen, Kirsten Svenstrup, Merete Karlsborg, Helle Thagesen, Morten Blaabjerg, Ásta Theódórsdóttir, Elisabeth Gundtoft Elmo, Anette Torvin Møller, Niels Anker Pedersen, Niels Kirkegaard, Kirsten Møller, Peter Garred

Publikation: Bidrag til tidsskriftArtikelForskningpeer review

Abstract

Background: The complement system has been suggested to be involved in the pathophysiology of amyotrophic lateral sclerosis (ALS), a progressive motor neuron disease. In the present study, we compared levels of selected complement markers to clinical outcome in ALS patients.

Methods: This observational, explorative cohort study included 92 ALS patients, 61 neurological controls (NCs) admitted for suspected aneurysmal subarachnoid haemorrhage, and 96 neurologically healthy controls (NHCs). Peripheral blood and cerebrospinal fluid (CSF) were obtained for the measurement of ficolin-1, -2, and -3; collectin-11, MBL, MASP-3, MAP-1, C4, C3, PTX-3, and complement activation products C4c, C3bc, and sC5b-9. We recorded clinical outcomes of ALS patients for 24 to 48 months after inclusion in order to analyse the effects of the complement markers on survival time.

Results: Compared with both control groups, ALS patients exhibited increased collectin-11, C4 and sC5b-9 in plasma, as well as increased ficolin-3 in CSF. Ficolin-2 was significantly decreased in plasma of the ALS patients compared with NHCs, but not with NCs. The concentration of collectin-11, C3 and C3bc correlated negatively with the revised ALS functional rating scale (ALSFRS-R). No association was found between levels of complement markers and survival as estimated by hazard ratios.

Conclusion: ALS patients exhibit aberrant expression of selected mediators of the lectin complement pathway as well as increased activation of the terminal complement pathway, corroborating the notion that the complement system might be involved in the pathophysiology of ALS.

OriginalsprogEngelsk
Sider (fra-til)1043-1053
Antal sider11
TidsskriftJournal of Inflammation Research
Vol/bind2021
Udgave nummer14
DOI
StatusUdgivet - 2021

Bibliografisk note

© 2021 Kjældgaard et al.

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