Complement-dependent pathogenicity of brain-specific antibodies in cerebrospinal fluid

Nasrin Asgari, Reza Khorooshi, Søren T. Lillevang, Trevor Owens

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review

    Abstrakt

    The specificity and potential pathogenicity of autoantibodies vary between neurological diseases. It is often unclear whether their detection in cerebrospinal fluid (CSF) is a consequence or a cause of pathology. The goal was to test whether administration of brain-specific antibodies into CSF would be sufficient for pathology. Purified immunoglobulin G from a neuromyelitis optica patient was injected intrathecally with complement to naïve mice. Histopathological analysis at 7. days revealed damage to the ependyma, disruption of the CSF parenchymal barrier and pathologic lesions, distant from the site of injection. In the absence of complement there was no pathology. Autoantibody and complement in CSF are thus sufficient to initiate a pathologic cascade.

    OriginalsprogEngelsk
    Sider (fra-til)76-82
    Antal sider7
    TidsskriftJournal of Neuroimmunology
    Vol/bind254
    Udgave nummer1-2
    DOI
    StatusUdgivet - 15 jan. 2013

    Fingeraftryk Udforsk hvilke forskningsemner 'Complement-dependent pathogenicity of brain-specific antibodies in cerebrospinal fluid' indeholder.

    Citationsformater