Comparison of the action of calcium antagonists on basophil histamine release

C. Bindslev Jensen*, P. Clementsen, P. Stahl Skov, U. G. Svendsen, O. Thastrup, S. Norn

*Corresponding author af dette arbejde

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    Abstract

    The inhibitory capacity of calcium antagonists on basophil histamine release was examined in allergic patients and in controls. All dihydropyridines tested (nifedipine, nimodipine, nitrendipine, nicardipine, felodipine) dose‐dependently inhibited anti‐IgE‐ and A23187‐induced release with an order of potency of felodipine > nicardipine > nifedipine = nimodipine = nitrendipine. Only the inhibition induced by felodipine and nicardipine on anti‐IgE‐induced release could be counteracted by increasing extracellular calcium. Diltiazem, not belonging to the dihydropyridines, was a weak inhibitor. A combination of felodipine and verapamil in low concentrations exerted a synergistic inhibitory effect on histamine release, whereas this was not the case with other combinations of antagonists. The results suggest differences in the mode of action of the 1.4‐dihydropyridines. This might be of significance in the search for calcium antagonists suitable in the treatment of allergic diseases.

    OriginalsprogEngelsk
    Sider (fra-til)441-446
    Antal sider6
    TidsskriftAllergy
    Vol/bind42
    Udgave nummer6
    DOI
    StatusUdgivet - aug. 1987

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