TY - JOUR

T1 - Comparison between reference values for 201Thallium uptake and washout from the myocardium after exercise and after dipyridamole

AU - Munck, O.

AU - Madsen, P. V.

AU - Kelbaek, H.

AU - Godtfredsen, J.

PY - 1993/7

Y1 - 1993/7

N2 - Summary. A slow washout of 201Thallium has a high diagnostic and prognostic value for coronary artery disease. The aim of the present work was to contribute with reference data on 201T1 uptake and washout from the myocardium. With a quantitative method using circumferential profiles and interpolative background subtraction we performed 201T1 myocardial imaging in two groups of subjects with a low probability of coronary artery disease. Washout in per cent is defined as (1‐D/I) 100, where D is the delayed uptake rate and I the initial uptake rate. In group A (n=16) myocardial hyperaemia was induced by maximal exercise, in group B (n=15) by intravenous infusion of dipyridamole. In group A, the mean washout was 52%, and in group B it was 34% (P < 0.001). The delayed uptake rate D was significantly higher after dipyridamole, 58.4 cps, than after exercise, 44.5 cps (P < 0.05). There was no significant difference in I between the two groups. The findings regarding D and I explain that the washout is slower after dipyridamole than after exercise, as the mean D/I ratio was 0.48 in group A and 0.66 in group B (P < 00.1).

AB - Summary. A slow washout of 201Thallium has a high diagnostic and prognostic value for coronary artery disease. The aim of the present work was to contribute with reference data on 201T1 uptake and washout from the myocardium. With a quantitative method using circumferential profiles and interpolative background subtraction we performed 201T1 myocardial imaging in two groups of subjects with a low probability of coronary artery disease. Washout in per cent is defined as (1‐D/I) 100, where D is the delayed uptake rate and I the initial uptake rate. In group A (n=16) myocardial hyperaemia was induced by maximal exercise, in group B (n=15) by intravenous infusion of dipyridamole. In group A, the mean washout was 52%, and in group B it was 34% (P < 0.001). The delayed uptake rate D was significantly higher after dipyridamole, 58.4 cps, than after exercise, 44.5 cps (P < 0.05). There was no significant difference in I between the two groups. The findings regarding D and I explain that the washout is slower after dipyridamole than after exercise, as the mean D/I ratio was 0.48 in group A and 0.66 in group B (P < 00.1).

KW - Thallium

KW - background subtraction

KW - myocardial imaging

KW - reference groups

UR - http://www.scopus.com/inward/record.url?scp=0027234784&partnerID=8YFLogxK

U2 - 10.1111/j.1475-097X.1993.tb00341.x

DO - 10.1111/j.1475-097X.1993.tb00341.x

M3 - Article

C2 - 8370240

AN - SCOPUS:0027234784

VL - 13

SP - 419

EP - 427

JO - Clinical Physiology and Functional Imaging

JF - Clinical Physiology and Functional Imaging

SN - 1475-0961

IS - 4

ER -