Comparison between reference values for 201Thallium uptake and washout from the myocardium after exercise and after dipyridamole

O. Munck, P. V. Madsen, H. Kelbaek, J. Godtfredsen

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    Summary. A slow washout of 201Thallium has a high diagnostic and prognostic value for coronary artery disease. The aim of the present work was to contribute with reference data on 201T1 uptake and washout from the myocardium. With a quantitative method using circumferential profiles and interpolative background subtraction we performed 201T1 myocardial imaging in two groups of subjects with a low probability of coronary artery disease. Washout in per cent is defined as (1‐D/I) 100, where D is the delayed uptake rate and I the initial uptake rate. In group A (n=16) myocardial hyperaemia was induced by maximal exercise, in group B (n=15) by intravenous infusion of dipyridamole. In group A, the mean washout was 52%, and in group B it was 34% (P < 0.001). The delayed uptake rate D was significantly higher after dipyridamole, 58.4 cps, than after exercise, 44.5 cps (P < 0.05). There was no significant difference in I between the two groups. The findings regarding D and I explain that the washout is slower after dipyridamole than after exercise, as the mean D/I ratio was 0.48 in group A and 0.66 in group B (P < 00.1).

    Sider (fra-til)419-427
    Antal sider9
    TidsskriftClinical Physiology
    Udgave nummer4
    StatusUdgivet - jul. 1993

    Fingeraftryk Udforsk hvilke forskningsemner 'Comparison between reference values for <sup>201</sup>Thallium uptake and washout from the myocardium after exercise and after dipyridamole' indeholder.