Common variants at VRK2 and TCF4 conferring risk of schizophrenia

Stacy Steinberg, Simone de Jong, Ole A. Andreassen, Thomas Werge, Anders D. Børglum, Ole Mors, Preben B. Mortensen, Omar Gustafsson, Javier Costas, Olli P.H. Pietiläinen, Ditte Demontis, Sergi Papiol, Johanna Huttenlocher, Manuel Mattheisen, René Breuer, Evangelos Vassos, Ina Giegling, Gillian Fraser, Nicholas Walker, Annamari Tuulio-HenrikssonJaana Suvisaari, Jouko Lönnqvist, Tiina Paunio, Ingrid Agartz, Ingrid Melle, Srdjan Djurovic, Eric Strengman, Gesche Jürgens, Birte Glenthøj, Lars Terenius, David M. Hougaard, Torben Ørntoft, Carsten Wiuf, Michael Didriksen, Mads V. Hollegaard, Merete Nordentoft, Ruud van Winkel, Gunter Kenis, Lilia Abramova, Vasily Kaleda, Manuel Arrojo, Julio Sanjuán, Celso Arango, Swetlana Sperling, Moritz Rossner, Michele Ribolsi, Valentina Magni, Alberto Siracusano, Claus Christiansen, Lambertus A. Kiemeney, Jan Veldink, Leonard van den Berg, Andres Ingason, Pierandrea Muglia, Robin Murray, Markus M. Nöthen, Engilbert Sigurdsson, Hannes Petursson, Unnur Thorsteinsdottir, Augustine Kong, I. Alex Rubino, Marc de Hert, János M. Réthelyi, István Bitter, Erik G. Jönsson, Vera Golimbet, Angel Carracedo, Hannelore Ehrenreich, Nick Craddock, Michael J. Owen, Michael C. O'Donovan, Mirella Ruggeri, Sarah Tosato, Leena Peltonen, Roel A. Ophoff, David A. Collier, David St Clair, Marcella Rietschel, Sven Cichon, Hreinn Stefansson, Dan Rujescu, Kari Stefansson*

*Corresponding author af dette arbejde

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review

    Abstrakt

    Common sequence variants have recently joined rare structural polymorphisms as genetic factors with strong evidence for association with schizophrenia. Here we extend our previous genome-wide association study and meta-analysis (totalling 7 946 cases and 19 036 controls) by examining an expanded set of variants using an enlarged follow-up sample (up to 10 260 cases and 23 500 controls). In addition to previously reported alleles in the major histocompatibility complex region, near neurogranin (NRGN) and in an intron of transcription factor 4 (TCF4), we find two novel variants showing genome-wide significant association: rs2312147[C], upstream of vaccinia-related kinase 2 (VRK2) [odds ratio (OR) = 1.09, P = 1.9 × 10-9] and rs4309482[A], between coiled-coiled domain containing 68 (CCDC68) and TCF4, about 400 kb from the previously described risk allele, but not accounted for by its association (OR = 1.09, P = 7.8 × 10-9).

    OriginalsprogEngelsk
    Artikelnummerddr325
    Sider (fra-til)4076-4081
    Antal sider6
    TidsskriftHuman Molecular Genetics
    Vol/bind20
    Udgave nummer20
    DOI
    StatusUdgivet - 1 okt. 2011

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