Common nonsynonymous variants in PCSK1 confer risk of obesity

Michael Benzinou, John W.M. Creemers, Helene Choquet, Stephane Lobbens, Christian Dina, Emmanuelle Durand, Audrey Guerardel, Philippe Boutin, Beatrice Jouret, Barbara Heude, Beverley Balkau, Jean Tichet, Michel Marre, Natascha Potoczna, Fritz Horber, Catherine Le Stunff, Sebastien Czernichow, Annelli Sandbaek, Torsten Lauritzen, Knut Borch-JohnsenGitte Andersen, Wieland Kiess, Antje Körner, Peter Kovacs, Peter Jacobson, Lena M.S. Carlsson, Andrew J. Walley, Torben Jørgensen, Torben Hansen, Oluf Pedersen, David Meyre, Philippe Froguel

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    Abstrakt

    Mutations in PCSK1 cause monogenic obesity. To assess the contribution of PCSK1 to polygenic obesity risk, we genotyped tag SNPs in a total of 13,659 individuals of European ancestry from eight independent case-control or family-based cohorts. The nonsynonymous variants rs6232, encoding N221D, and rs6234-rs6235, encoding the Q665E-S690T pair, were consistently associated with obesity in adults and children (P = 7.27 × 10-8 and P = 2.31 × 10-12, respectively). Functional analysis showed a significant impairment of the N221D-mutant PC1/3 protein catalytic activity.

    OriginalsprogEngelsk
    Sider (fra-til)943-945
    Antal sider3
    TidsskriftNature Genetics
    Vol/bind40
    Udgave nummer8
    DOI
    StatusUdgivet - 1 aug. 2008

    Fingeraftryk Udforsk hvilke forskningsemner 'Common nonsynonymous variants in PCSK1 confer risk of obesity' indeholder.

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