TY - JOUR
T1 - Cognitive Functions in Middle Aged Individuals Are Related to Metabolic Disturbances and Aerobic Capacity
T2 - A Cross-Sectional Study
AU - Pedersen, Maria
AU - Pedersen, Karin Kaereby
AU - Bruunsgaard, Helle
AU - Krabbe, Karen Suarez
AU - Thomsen, Carsten
AU - Færch, Kristine
AU - Pedersen, Bente Klarlund
AU - Mortensen, Erik Lykke
PY - 2012/12/12
Y1 - 2012/12/12
N2 - Aims: Metabolic disturbances may contribute to cognitive dysfunction in patients with type 2 diabetes. We investigated the relation between cognitive impairment and metabolic deteriorations, low physical fitness, low-grade inflammation and abdominal obesity in middle aged individuals. Methods: We conducted a cross-sectional study including 40 to 65 year-old patients with type 2 diabetes and limited co morbidity (N = 56), age-matched individuals with impaired glucose tolerance (N = 56) as well as age-matched controls with normal glucose tolerance (N = 72). Specific cognitive functions were assessed with focus on verbal memory, processing speed, executive functions, and a composite overall mean score. Oral glucose tolerance test, VO2max test, systemic inflammation, DXA scanning and abdominal MRI were measured. Results: Multiple linear regression analyses adjusting for age, gender and verbal intelligence demonstrated that a low score in processing speed, executive functions and overall cognitive function were related to high fasting C-peptide, as well as low insulin sensitivity, beta-cell function and VO2max. Measurements of blood glucose, obesity and inflammation were not associated with cognitive function. Conclusion: Low cognitive scores are seen in middle aged individuals with hyperinsulinemia, low insulin sensitivity, beta-cell function and low aerobic capacity. These findings emphasize the importance of appropriate lifestyle and not only blood glucose control in prevention of cognitive disability.
AB - Aims: Metabolic disturbances may contribute to cognitive dysfunction in patients with type 2 diabetes. We investigated the relation between cognitive impairment and metabolic deteriorations, low physical fitness, low-grade inflammation and abdominal obesity in middle aged individuals. Methods: We conducted a cross-sectional study including 40 to 65 year-old patients with type 2 diabetes and limited co morbidity (N = 56), age-matched individuals with impaired glucose tolerance (N = 56) as well as age-matched controls with normal glucose tolerance (N = 72). Specific cognitive functions were assessed with focus on verbal memory, processing speed, executive functions, and a composite overall mean score. Oral glucose tolerance test, VO2max test, systemic inflammation, DXA scanning and abdominal MRI were measured. Results: Multiple linear regression analyses adjusting for age, gender and verbal intelligence demonstrated that a low score in processing speed, executive functions and overall cognitive function were related to high fasting C-peptide, as well as low insulin sensitivity, beta-cell function and VO2max. Measurements of blood glucose, obesity and inflammation were not associated with cognitive function. Conclusion: Low cognitive scores are seen in middle aged individuals with hyperinsulinemia, low insulin sensitivity, beta-cell function and low aerobic capacity. These findings emphasize the importance of appropriate lifestyle and not only blood glucose control in prevention of cognitive disability.
UR - http://www.scopus.com/inward/record.url?scp=84871248750&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0051132
DO - 10.1371/journal.pone.0051132
M3 - Article
C2 - 23251434
AN - SCOPUS:84871248750
SN - 1932-6203
VL - 7
JO - PloS one
JF - PloS one
IS - 12
M1 - e51132
ER -