Clinical trial: Long-term use of proton pump inhibitors in primary care patients - A cross sectional analysis of 901 patients

C. Reimer, P. Bytzer

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Abstrakt

Background The use of proton pump inhibitors (PPIs) is extensive. While the incidence of new treatments remains stable, the prevalence of long-term treatment is rising. Studies have shown that up to 70% of patients on chronic acid suppression lack a verified indication for treatment. Aims To investigate primary care patient characteristics associated with long-term use of PPIs. Methods A cross-sectional analysis of 42 634 patients registered with 22 general practitioners was performed. Patients with prescriptions of ≥120 tablets/year were defined as long-term users. A survey of a subgroup of patients without verified indication was performed. Results In all, 901 (2.1%) patients were long-term treated. Verified indications for treatment were identified for 247/901 (27%). An upper GI endoscopy had been performed in 418 patients (46%). Of the 194/654 without verified indication who participated in the survey, 71% reported heartburn/acid regurgitation as the reason for therapy. On-demand therapy was reported by 43/194 (22%) and previous attempts to withdraw by 119/194 (61%). Conclusions The prevalence of PPI long-term treatment among primary care patients is 2.1%. The main reason for treatment is reflux symptoms or verified GERD. Rationalization of use of PPIs is possible as daily treatment without attempts to discontinue is frequently observed.

OriginalsprogEngelsk
Sider (fra-til)725-732
Antal sider8
TidsskriftAlimentary Pharmacology and Therapeutics
Vol/bind30
Udgave nummer7
DOI
StatusUdgivet - 1 okt. 2009

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