Circulating YKL-40 in myelofibrosis a potential novel biomarker of disease activity and the inflammatory state

Mads Emil Bjørn, Christen Lykkegaard Andersen, Morten Krogh Jensen, Hans C. Hasselbalch

Publikation: Bidrag til tidsskriftArtikelForskningpeer review

Abstrakt

Chronic myeloproliferative neoplasms (MPN), encompassing essential thrombocythaemia (ET), polycythaemia vera (PV) and myelofibrosis (PMF), are featured by a chronic inflammatory state which is pronounced in myelofibrosis The value of YKL-40 as a biomarker of disease burden has been demonstrated in several different diseases, including cancer, diabetes mellitus and cardiovascular diseases. A state of chronic inflammation is shared by them all, YKL-40 also being involved in the severity of chronic endothelial inflammation, which today is considered of crucial importance for the development of atherosclerosis. The MPNs being cancers with a heavy burden of cardiovascular diseases we hypothesised that circulating YKL-40 might reflect the inflammatory process and potentially serve as a novel disease marker. Using ELISA, we measured YKL-40 in 15 patients with ET, 16 patients with PV, 17 patients with PMF and 30 healthy controls. YKL-40 was significantly elevated in PMF vs. control subjects, PMF levels median 43 ng/mL vs. controls median 28 ng/mL, P = 0.033. An increase from ET over PV may reflect the integrated impact of disease processes in MPNs.

OriginalsprogEngelsk
Sider (fra-til)224-228
Antal sider5
TidsskriftEuropean Journal of Haematology
Vol/bind93
Udgave nummer3
DOI
StatusUdgivet - sep. 2014

Fingeraftryk Udforsk hvilke forskningsemner 'Circulating YKL-40 in myelofibrosis a potential novel biomarker of disease activity and the inflammatory state' indeholder.

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