Abstract
The excretion of collagen metabolites and circulating androgens was measured in ten males suffering from progressive systemic sclerosis. Significantly higher levels of sex hormone-binding globuline, total testosterone and dihydrotestosterone (DHT) (P<0.01), and total oestradiol (P<0.05), were found in patients when compared with age-matched controls. Urinary excretion of hydroxyproline in patients was found to correlate significantly with total testosterone (P=0.035), with DHT (P=0.005) and dehydroepiandrosteronsulphate (DHEAS) (P=0.034). Similarly the hydroxyproline peptide fraction was found to correlate significantly with total testosterone (P=0.037), with DHT (P=0.005) and with DHEAS (P=0.008). Hydroxylysine peptide in the urine correlated significantly with free testosterone (P=0.035) and DHT (P=0.040). Oestrogens did not correlate with urinary excretion of collagen metabolites. These findings suggest that androgens may play a role in the pathogenesis of scleroderma in male patients.
Originalsprog | Engelsk |
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Sider (fra-til) | 289-291 |
Antal sider | 3 |
Tidsskrift | Archives of Dermatological Research |
Vol/bind | 283 |
Udgave nummer | 5 |
DOI | |
Status | Udgivet - 1 jul. 1991 |