Circulating androgens in male patients suffering from systemic scleroderma

G. B.E. Jemec*, J. H. Sindrup

*Corresponding author af dette arbejde

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    Abstract

    The excretion of collagen metabolites and circulating androgens was measured in ten males suffering from progressive systemic sclerosis. Significantly higher levels of sex hormone-binding globuline, total testosterone and dihydrotestosterone (DHT) (P<0.01), and total oestradiol (P<0.05), were found in patients when compared with age-matched controls. Urinary excretion of hydroxyproline in patients was found to correlate significantly with total testosterone (P=0.035), with DHT (P=0.005) and dehydroepiandrosteronsulphate (DHEAS) (P=0.034). Similarly the hydroxyproline peptide fraction was found to correlate significantly with total testosterone (P=0.037), with DHT (P=0.005) and with DHEAS (P=0.008). Hydroxylysine peptide in the urine correlated significantly with free testosterone (P=0.035) and DHT (P=0.040). Oestrogens did not correlate with urinary excretion of collagen metabolites. These findings suggest that androgens may play a role in the pathogenesis of scleroderma in male patients.

    OriginalsprogEngelsk
    Sider (fra-til)289-291
    Antal sider3
    TidsskriftArchives of Dermatological Research
    Vol/bind283
    Udgave nummer5
    DOI
    StatusUdgivet - 1 jul. 1991

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