Recent advances in magnetic resonance imaging have made it possible to visualize and quantify flow of cerebrospinal fluid (CSF) in the brain. The net flow of CSF through the cerebral aqueduct was used to measure CSF production in six normal volunteers at different times during a 24-h period. CSF production varied greatly both intra- and interindividually. The average CSF production in each time interval showed a clear tendency to circadian variation, with a minimum production 30% of maximum values (12 ± 7 ml/h) ~1800 h and a nightly peak production ~0200 h of 42 ± 2 ml/h. The total CSF production during the whole 24-h period, calculated as an average of all measurements, was 650 ml for the whole group and 630 ml for repeated measurements in each time interval in one of the volunteers.
|Tidsskrift||American Journal of Physiology - Regulatory Integrative and Comparative Physiology|
|Udgave nummer||1 31-1|
|Status||Udgivet - 1 jan. 1992|