Chronic kidney disease in patients with the Philadelphia-negative chronic myeloproliferative neoplasms

Background: The progression of kidney function and frequency of chronic kidney disease (CKD) in patients with the Philadelphia-negative myeloproliferative neoplasms (MPN) is unknown, although CKD is linked to increased mortality. Methods: This longitudinal retrospective study evaluates the estimated glomerular filtration rate (eGFR) in 143 MPN patients over a period of 9 years. Results: 29% of patients had CKD stage 3 or 4 at time of diagnosis. 20% of patients had a rapid annual loss of eGFR (>3mL/min/1.73m²) and eGFR was negatively correlated to monocyte and neutrophil counts. Conclusion: Kidney impairment might contribute to the increased mortality observed in MPN patients.