Chronic kidney disease in patients with the Philadelphia-negative chronic myeloproliferative neoplasms

Alexander Sidelmann Christensen*, Jonas Bech Møller, Hans Carl Hasselbalch

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftArtikelForskningpeer review

Abstract

Background: The progression of kidney function and frequency of chronic kidney disease (CKD) in patients with the Philadelphia-negative myeloproliferative neoplasms (MPN) is unknown, although CKD is linked to increased mortality. Methods: This longitudinal retrospective study evaluates the estimated glomerular filtration rate (eGFR) in 143 MPN patients over a period of 9 years. Results: 29% of patients had CKD stage 3 or 4 at time of diagnosis. 20% of patients had a rapid annual loss of eGFR (>3mL/min/1.73m2) and eGFR was negatively correlated to monocyte and neutrophil counts. Conclusion: Kidney impairment might contribute to the increased mortality observed in MPN patients.

OriginalsprogEngelsk
Sider (fra-til)490-495
Antal sider6
TidsskriftLeukemia Research
Vol/bind38
Udgave nummer4
DOI
StatusUdgivet - apr. 2014

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Udforsk hvilke forskningsemner 'Chronic kidney disease in patients with the Philadelphia-negative chronic myeloproliferative neoplasms' indeholder.

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