Cholecystokinin-stimulated and postprandial serum concentrations in bile acids in alcoholic liver cirrhosis

H. Kelbaek, K. Linnet, H. Stimpel, J. Glenthøj, H. F. Thomsen, M. Bahnsen

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    Abstrakt

    This investigation was undertaken to examine the alterations in serum bile acid concentration after intravenous administration of cholecystokinin and a standard meal in 13 patients with alcoholic cirrhosis. Total 3α-hydroxy bile acids in serum (SBA) were monitored for 2 hr after injection of cholecystokinin and for 3 h after the standard meal. The medium fasting value of SBA was 39.9 μmol/l (range, 3.2-148 μmol/l). The increase in SBA after cholecystokinin started earlier and lasted shorter than after standard meal stimulation (median, 30 min and 120 min, respectively). The appropriate relative peak levels of SBA were 173% and 212% of the fasting value. The increments were significant (P < 0.01) within groups but insignificant between groups. Day-to-day variation of postprandial SBA was more pronounced than after cholecystokinin stimulation. The difference, however, was insignificant. An inverse correlation was detected between both fasting and stimulated peak levels of SBA and P-coagulation factors 2, 7, and 10.

    OriginalsprogEngelsk
    Sider (fra-til)655-660
    Antal sider6
    TidsskriftScandinavian journal of gastroenterology
    Vol/bind19
    Udgave nummer5
    StatusUdgivet - 4 okt. 1984

    Fingeraftryk Udforsk hvilke forskningsemner 'Cholecystokinin-stimulated and postprandial serum concentrations in bile acids in alcoholic liver cirrhosis' indeholder.

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