Chemical exposure in manufacture of phenoxy herbicides and chlorophenols and in spraying of phenoxy herbicides

Timo Kauppinen*, Manolis Kogevinas, Eric Johnson, Heiko Becher, Pier‐Alberto ‐A Bertazzi, H. Bas Bueno de Mesquita, David Coggon, Lois Green, Margareta Littorin, Elsebeth Lynge, John Mathews, Manfred Neuberger, John Osman, Brian Pannett, Neil Pearce, Regina Winkelmann, Rodolfo Saracci

*Corresponding author af dette arbejde

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review


    Exposure patterns are reported for manufacturing and sprayer cohorts incorporated in the “IARC International Register of Workers exposed to Phenoxy Herbicides and Contaminants.” Information was based on company questionnaires, company reports, plant visits, and serum 2,3,7,8‐TCDD measurements. In addition to phenoxy herbicides and chlorophenols, workers in manufacturing plants may have been exposed to raw materials, process chemicals, other agents synthesized or formulated, and impurities of all these agents. Sprayers also had a complex exposure pattern, including phenoxy herbicides and some other pesticides, their carriers and additives, and residues of chemicals formed during manufacture. Occurrence of agents, including dioxins, varied between countries. Biological monitoring and industrial hygiene data were rarely available, most since the late 1970s. Exposure of workers depended mainly on the jobs they performed, but several factors influenced level of exposure. A quantitative exposure classification is not feasible in this study. Semiquantitative exposure estimates may be derived through a critical interpretation of biological monitoring and industrial hygiene data together with individual work histories. © 1993 Wiley‐Liss, Inc.

    Sider (fra-til)903-920
    Antal sider18
    TidsskriftAmerican Journal of Industrial Medicine
    Udgave nummer6
    StatusUdgivet - jun. 1993


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