Changes in cerebral blood flow after acetazolamide: An experimental study comparing near-infrared spectroscopy and SPECT

H. W. Schytz, T. Wienecke, L. T. Jensen, J. Selb, D. A. Boas, M. Ashina

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    Abstrakt

    Background and purpose: It is important to find a reliable and bedside method, which can estimate the cerebral blood flow (CBF) of patients in clinical settings. Estimation of CBF by calculating a blood flow index (BFI) using continuous wave near-infrared spectroscopy (CW-NIRS) and indocyanine green (ICG) as an iv tracer has been proposed to be a feasible and promising method. To validate if the BFI method can detect relative changes in CBF we compared data with the established method 133Xenon single photon emission computer tomography (133Xe-SPECT). Methods: Ten healthy subjects were investigated before and after a bolus of acetazolamide. NIRS data were obtained using a multi source detector separation configuration in order to assess a corrected BFI (BFIcorr) value, which attempts to eliminate contamination of skin blood flow. Results: Data obtained showed no significant correlation between CBF changes measured by 133Xe-SPECT and BFI corr (0.133, P = 0.732). After acetazolamide, a 49% increase in CBF was detected using the 133Xe-SPECT method, whereas no changes in any ICG variables were observed after acetazolamide. Conclusion: The study shows that it is not possible to obtain reliable BFI data, which reflect changes in CBF after acetazolamide infusion, using the CW-NIRS and ICG method.

    OriginalsprogEngelsk
    Sider (fra-til)461-467
    Antal sider7
    TidsskriftEuropean Journal of Neurology
    Vol/bind16
    Udgave nummer4
    DOI
    StatusUdgivet - 1 apr. 2009

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    Udforsk hvilke forskningsemner 'Changes in cerebral blood flow after acetazolamide: An experimental study comparing near-infrared spectroscopy and SPECT' indeholder.

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