Changes in blood pressure and renal function in patients with type I (insulin-dependent) diabetes mellitus prior to clinical diabetic nephropathy

T. Jensen, K. Borch-Johnsen, T. Deckert

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    Abstrakt

    58 type I (insulin-dependent) diabetic patients who in the period 1975 to 1981 developed clinical diabetic nephropathy (urinary protein excretion > 0.5 g/day) (group I) were matched in pairs to 58 patients not developing nephropathy (group II) according to sex (29 males and 29 females), age (33 years (18-46) vs. 33 years (15-48)) and diabetes duration (19 years (6-39) vs. 19 years (6-42)). Supine blood pressure measured during hospitalization and weight x 100/serum creatinine were evaluated as to diabetes duration in the periods > 10, 10-6, 5-1 years prior to and at the onset of proteinuria. There was no difference in initial blood pressure (124/78 ± 11/10 mmHg (group I) vs. 125/79 ± 11/10 mmHg (group II)). Diastolic blood pressure was higher from 10-6 (85 ± 9 vs. 80 ± 7 mmHg; p < 0.05) and systolic blood pressure from 5-1 (138 ± 17 vs. 129 ± 17 mmHg; p < 0.01) years before onset of proteinuria in group I compared with group II. There was no difference in weight x 100/serum creatinine initially (87 ± 17 kg/μmol/l (group I) vs. 88 ± 13 kg/μmol/l (group II) but from the period 5-1 years prior to the onset proteinuria it was reduced in group I (80 ± 14 kg/μmol/l) vs. group II (86 ± 14 kg/μmol/l); (p < 0.05). In conclusion, there was no initial difference in blood pressure and renal function between type I diabetic patients who later developed clinical diabetic nephropathy and those who didn't. Increase in blood pressure starts 5-10 years and renal function impairs 1-5 years before the onset of proteinuria.

    OriginalsprogEngelsk
    Sider (fra-til)159-162
    Antal sider4
    TidsskriftDiabetes Research
    Vol/bind4
    Udgave nummer4
    StatusUdgivet - 1 jan. 1987

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